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Doxycycline and Brain herniation - a phase IV clinical study of FDA data

Summary:

Brain herniation is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are female, 20-29 old, also take Vancomycin, and have Disseminated intravascular coagulation.

The phase IV clinical study analyzes which people have Brain herniation when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Brain herniation?

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull) is found to be associated with 337 drugs and 975 conditions by eHealthMe. Check the latest studies of Brain herniation.

On Aug, 08, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 19 people (0.03%) have Brain herniation.

Could Doxycycline cause Brain herniation?

Among these 19 people:

What is the gender of people who have Brain herniation when taking Doxycycline? *

  • female: 52.94 %
  • male: 47.06 %

What is the age of people who have Brain herniation when taking Doxycycline? *

  • 0-1: 0.0 %
  • 2-9: 6.25 %
  • 10-19: 6.25 %
  • 20-29: 56.25 %
  • 30-39: 0.0 %
  • 40-49: 18.75 %
  • 50-59: 0.0 %
  • 60+: 12.5 %

What are other drugs people take besides Doxycycline? *

  1. Vancomycin: 6 people, 31.58%
  2. Retin-A: 5 people, 26.32%
  3. Triamcinolone: 5 people, 26.32%
  4. Nuvaring: 5 people, 26.32%
  5. Ketoconazole: 5 people, 26.32%
  6. Fluconazole: 3 people, 15.79%
  7. Levophed: 3 people, 15.79%
  8. Prilosec: 3 people, 15.79%
  9. Azithromycin: 3 people, 15.79%
  10. Cleocin: 3 people, 15.79%

What are other side effects people have besides Brain herniation? *

  1. Subarachnoid Haemorrhage (blood leaks into the space between two membranes that surround the brain): 9 people, 47.37%
  2. Subdural Haematoma (blood collects between the skull and the surface of the brain): 7 people, 36.84%
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 31.58%
  4. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 6 people, 31.58%
  5. Hydrocephalus (water on the brain): 5 people, 26.32%
  6. Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 5 people, 26.32%
  7. Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 5 people, 26.32%
  8. Urinary Tract Infection: 4 people, 21.05%
  9. Pharyngeal Abscess: 4 people, 21.05%
  10. Cerebral Infarction (less blood supply to brain resulting tissue damage): 4 people, 21.05%

What are the existing conditions these people have? *

  1. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 21.05%
  2. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 3 people, 15.79%
  3. Hypotension (abnormally low blood pressure): 3 people, 15.79%
  4. Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 15.79%
  5. Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 10.53%
  6. Muscle Spasms (muscle contraction): 2 people, 10.53%
  7. Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 10.53%
  8. Viral Infection: 1 person, 5.26%
  9. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.26%
  10. Immunodeficiency Common Variable: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Brain herniation?

- Check whether Brain herniation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Brain herniation treatments and more:

How severe was Brain herniation and when was it recovered:

Expand to all the drugs that have ingredients of doxycycline hyclate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain herniation:

Browse all the conditions that are associated with Brain herniation:

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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