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Doxycycline and Oesophageal irritation - a phase IV clinical study of FDA data

Summary:

Oesophageal irritation is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Epiduo, and have Acne cystic.

The phase IV clinical study analyzes which people have Oesophageal irritation when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Oesophageal irritation?

Oesophageal irritation is found to be associated with 72 drugs and 176 conditions by eHealthMe. Check the latest studies of Oesophageal irritation.

On Jul, 16, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 15 people (0.03%) have Oesophageal irritation.

Could Doxycycline cause Oesophageal irritation?

Among these 15 people:

How long have people been on Doxycycline when they have Oesophageal irritation? *

  • < 1 month: 61.54 %
  • 1 - 6 months: 38.46 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Oesophageal irritation when taking Doxycycline? *

  • female: 85.71 %
  • male: 14.29 %

What is the age of people who have Oesophageal irritation when taking Doxycycline? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 50.0 %
  • 30-39: 33.33 %
  • 40-49: 8.33 %
  • 50-59: 0.0 %
  • 60+: 8.33 %

What are other drugs people take besides Doxycycline? *

  1. Epiduo: 4 people, 26.67%
  2. Thalomid: 2 people, 13.33%
  3. Omega-3 Fatty Acids: 1 person, 6.67%
  4. Asa: 1 person, 6.67%

What are other side effects people have besides Oesophageal irritation? *

  1. Indigestion: 8 people, 53.33%
  2. Oesophageal Ulcer (ulcer of oesophagus): 6 people, 40.00%
  3. Swallowing Pain Or Burning: 5 people, 33.33%
  4. Stress And Anxiety: 5 people, 33.33%
  5. Oesophagitis (inflammation of oesophagus): 5 people, 33.33%
  6. Inflammation: 4 people, 26.67%
  7. Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 1 person, 6.67%
  8. Swallowing Difficulty: 1 person, 6.67%
  9. Chest Pain: 1 person, 6.67%

What are the existing conditions these people have? *

  1. Gastric Ulcer (stomach ulcer): 5 people, 33.33%
  2. Acne Cystic (skin problems that cause pimples): 5 people, 33.33%
  3. Stress And Anxiety: 4 people, 26.67%
  4. Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 2 people, 13.33%
  5. Pneumonia: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Oesophageal irritation?

- Check whether Oesophageal irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Oesophageal irritation treatments and more:

How severe was Oesophageal irritation and when was it recovered:

Expand to all the drugs that have ingredients of doxycycline hyclate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oesophageal irritation:

Browse all the conditions that are associated with Oesophageal irritation:

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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