Dyazide and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Dyazide (hydrochlorothiazide; triamterene), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Xanax, and have Hiv infection.

The phase IV clinical study analyzes which people have Anhedonia when taking Dyazide. It is created by eHealthMe based on reports of 11,105 people who have side effects when taking Dyazide from the FDA, and is updated regularly.

What is Dyazide?

Dyazide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 11,506 Dyazide users. Check the latest studies of Dyazide.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,509 drugs and 1,275 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Jul, 15, 2026

11,105 people reported to have side effects when taking Dyazide.
Among them, 95 people (0.86%) have Anhedonia.

Among these 95 people:

How long have people been on Dyazide when they have Anhedonia? *

What is the gender of people who have Anhedonia when taking Dyazide? *

female: 55.79 %
male: 44.21 %

What is the age of people who have Anhedonia when taking Dyazide? *

What are other drugs people take besides Dyazide? *

What are other side effects people have besides Anhedonia? *

Pain: 82 people, 86.32%
Stress And Anxiety: 82 people, 86.32%
Injury: 55 people, 57.89%
Emotional Distress: 45 people, 47.37%
Acute Kidney Failure: 38 people, 40.00%
Depression: 33 people, 34.74%
Spinal Osteoarthritis (joint cartilage loss in spine): 26 people, 27.37%
Dizziness: 26 people, 27.37%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 26 people, 27.37%
Hypoaesthesia (reduced sense of touch or sensation): 25 people, 26.32%

What are the existing conditions these people have? *

Hiv Infection: 19 people, 20.00%
Oedema (fluid collection in tissue): 17 people, 17.89%
Pain: 16 people, 16.84%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 15 people, 15.79%
Depression: 7 people, 7.37%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 6.32%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 4 people, 4.21%
Parkinson's Disease: 4 people, 4.21%
Protein S Deficiency: 4 people, 4.21%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 2 people, 2.11%

* Approximation only. Some reports may have incomplete information.

Do you take Dyazide and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dyazide:

Dyazide (11,506 reports)

Anhedonia treatments and more:

Anhedonia (51,943 reports)

How severe was Anhedonia and when was it recovered:

Anhedonia in Dyazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; triamterene:

Anhedonia and drugs with ingredients of hydrochlorothiazide; triamterene (298 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dyazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,509 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,275 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; triamterene (the active ingredients of Dyazide) and Dyazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.