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Eligard and Flat affect - a phase IV clinical study of FDA data

Summary:

Flat affect is reported as a side effect among people who take Eligard (leuprolide acetate), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Dexamethasone, and have Hypertonic bladder.

The phase IV clinical study analyzes which people have Flat affect when taking Eligard. It is created by eHealthMe based on reports of 44,585 people who have side effects when taking Eligard from the FDA, and is updated regularly.

What is Eligard?

Eligard has active ingredients of leuprolide acetate. It is often used in prostate cancer. eHealthMe is studying from 44,652 Eligard users. Check the latest studies of Eligard.

What is Flat affect?

Flat affect (absence of emotional response to a situation) is found to be associated with 291 drugs and 460 conditions by eHealthMe. Check the latest studies of Flat affect.

On Jul, 20, 2026

44,585 people reported to have side effects when taking Eligard.
Among them, 11 people (0.02%) have Flat affect.

Could Eligard cause Flat affect?

Among these 11 people:

How long have people been on Eligard when they have Flat affect? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Flat affect when taking Eligard? *

  • female: 0.0 %
  • male: 100 %

What is the age of people who have Flat affect when taking Eligard? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

What are other drugs people take besides Eligard? *

  1. Vesicare: 2 people, 18.18%
  2. Imodium: 2 people, 18.18%
  3. Dexamethasone: 2 people, 18.18%

What are other side effects people have besides Flat affect? *

  1. Weight Increased: 5 people, 45.45%
  2. Mobility Decreased (ability to move is reduced): 5 people, 45.45%
  3. Fatigue (feeling of tiredness): 5 people, 45.45%
  4. Weight Decreased: 5 people, 45.45%
  5. Back Pain: 5 people, 45.45%
  6. Prostatic Specific Antigen Increased: 5 people, 45.45%
  7. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 5 people, 45.45%
  8. Nausea (feeling of having an urge to vomit): 4 people, 36.36%
  9. Blood Urine Present: 4 people, 36.36%
  10. Depressed Mood: 4 people, 36.36%

What are the existing conditions these people have? *

  1. Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Eligard and have Flat affect?

- Check whether Flat affect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eligard:

Flat affect treatments and more:

How severe was Flat affect and when was it recovered:

Expand to all the drugs that have ingredients of leuprolide acetate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Eligard:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flat affect:

Browse all the conditions that are associated with Flat affect:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Eligard) and Eligard (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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