Esgic-plus and Chest pain - a phase IV clinical study of FDA data

Summary:

Chest pain is reported as a side effect among people who take Esgic-plus (acetaminophen; butalbital; caffeine), especially for people who are female, 40-49 old, also take Xanax, and have Pain.

The phase IV clinical study analyzes which people have Chest pain when taking Esgic-plus. It is created by eHealthMe based on reports of 239 people who have side effects when taking Esgic-plus from the FDA, and is updated regularly.

What is Esgic-plus?

Esgic-plus has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 269 Esgic-plus users. Check the latest studies of Esgic-plus.

What is Chest pain?

Chest pain is found to be associated with 3,469 drugs and 4,888 conditions by eHealthMe. Check the latest studies of Chest pain.

On Jul, 13, 2026

239 people reported to have side effects when taking Esgic-plus.
Among them, 20 people (8.37%) have Chest pain.

Among these 20 people:

What is the gender of people who have Chest pain when taking Esgic-plus? *

female: 72.22 %
male: 27.78 %

What is the age of people who have Chest pain when taking Esgic-plus? *

What are other drugs people take besides Esgic-plus? *

What are other side effects people have besides Chest pain? *

Nausea (feeling of having an urge to vomit): 7 people, 35.00%
Dizziness: 5 people, 25.00%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 25.00%
Pulmonary Embolism (blockage of the main artery of the lung): 5 people, 25.00%
Weakness: 4 people, 20.00%
Dyspnea (difficult or laboured breathing): 4 people, 20.00%
Fatigue (feeling of tiredness): 4 people, 20.00%
Joint Pain: 4 people, 20.00%
Chills (felling of cold): 4 people, 20.00%
Headache (pain in head): 4 people, 20.00%

What are the existing conditions these people have? *

Pain: 4 people, 20.00%
Prostate Cancer Metastatic: 3 people, 15.00%
Premenstrual Syndrome: 2 people, 10.00%
Acne (skin problems that cause pimples): 2 people, 10.00%
Type 1 Diabetes: 1 person, 5.00%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 5.00%
Osteoporosis (bones weak and more likely to break): 1 person, 5.00%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 5.00%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 1 person, 5.00%
Menstruation Irregular: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Esgic-plus and have Chest pain?

- Check whether Chest pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Esgic-plus:

Esgic-plus (269 reports)

Chest pain treatments and more:

Chest pain (363,501 reports)

How severe was Chest pain and when was it recovered:

Chest pain in Esgic-plus

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Chest pain and drugs with ingredients of acetaminophen; butalbital; caffeine (2,204 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Esgic-plus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chest pain:

Chest pain (3,469 drugs)

Browse all the conditions that are associated with Chest pain:

Chest pain (4,888 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Esgic-plus) and Esgic-plus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.