Estrace and Multiple myeloma - a phase IV clinical study of FDA data

Summary:

Multiple myeloma is reported as a side effect among people who take Estrace (estradiol), especially for people who are female, 60+ old, also take Prilosec, and have Osteopenia.

The phase IV clinical study analyzes which people have Multiple myeloma when taking Estrace. It is created by eHealthMe based on reports of 16,282 people who have side effects when taking Estrace from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Multiple myeloma?

Multiple myeloma (cancer of the plasma cells) is found to be associated with 1,107 drugs and 1,404 conditions by eHealthMe. Check the latest studies of Multiple myeloma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

16,282 people reported to have side effects when taking Estrace.
Among them, 43 people (0.26%) have Multiple myeloma.

Among these 43 people:

What is the gender of people who have Multiple myeloma when taking Estrace? *

female: 97.44 %
male: 2.56 %

What is the age of people who have Multiple myeloma when taking Estrace? *

What are other drugs people take besides Estrace? *

What are other side effects people have besides Multiple myeloma? *

Fatigue (feeling of tiredness): 29 people, 67.44%
Fever: 24 people, 55.81%
Stress And Anxiety: 23 people, 53.49%
Pain In Extremity: 23 people, 53.49%
Muscle Spasms (muscle contraction): 23 people, 53.49%
Back Pain: 23 people, 53.49%
Osteopenia (a condition where bone mineral density is lower than normal): 22 people, 51.16%
Fall: 20 people, 46.51%
Nausea (feeling of having an urge to vomit): 20 people, 46.51%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 20 people, 46.51%

What are the existing conditions these people have? *

Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 5 people, 11.63%
Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 11.63%
Stress And Anxiety: 1 person, 2.33%
Sleep Disorder: 1 person, 2.33%
Osteoporosis (bones weak and more likely to break): 1 person, 2.33%
Oedema (fluid collection in tissue): 1 person, 2.33%
Neuralgia (pain in one or more nerves): 1 person, 2.33%
Migraine (headache): 1 person, 2.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 2.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Estrace and have Multiple myeloma?

- Check whether Multiple myeloma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrace:

Estrace (16,703 reports)

Multiple myeloma treatments and more:

Multiple myeloma (516,725 reports)

Browse all side effects of Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple myeloma:

Multiple myeloma (1,107 drugs)

Browse all the conditions that are associated with Multiple myeloma:

Multiple myeloma (1,404 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.