Estradiol and Vaginal discharge - a phase IV clinical study of FDA data

Summary:

Vaginal discharge is reported as a side effect among people who take Estradiol (estradiol), especially for people who are 60+ old, have been taking the drug for < 1 month also take Synthroid, and have Pain.

The phase IV clinical study analyzes which people have Vaginal discharge when taking Estradiol. It is created by eHealthMe based on reports of 17,352 people who have side effects when taking Estradiol from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Vaginal discharge?

Vaginal discharge is found to be associated with 647 drugs and 1,199 conditions by eHealthMe. Check the latest studies of Vaginal discharge.

On Jul, 22, 2026

17,352 people reported to have side effects when taking Estradiol.
Among them, 53 people (0.31%) have Vaginal discharge.

Could Estradiol cause Vaginal discharge?

Among these 53 people:

How long have people been on Estradiol when they have Vaginal discharge? *

What is the age of people who have Vaginal discharge when taking Estradiol? *

What are other drugs people take besides Estradiol? *

What are other side effects people have besides Vaginal discharge? *

Vulvovaginal Pruritus (vulvovaginal severe itching): 8 people, 15.09%
Headache (pain in head): 7 people, 13.21%
Vaginal Bleeding: 6 people, 11.32%
Nausea (feeling of having an urge to vomit): 6 people, 11.32%
Abdominal Pain: 6 people, 11.32%
Fatigue (feeling of tiredness): 6 people, 11.32%
Back Pain: 5 people, 9.43%
Weight Decreased: 5 people, 9.43%
Hot Flush (sudden feelings of heat): 5 people, 9.43%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 4 people, 7.55%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 9.43%
Pain: 5 people, 9.43%
Atrophic Vulvovaginitis (inflammation of the vulva): 4 people, 7.55%
Vulvovaginal Dryness: 2 people, 3.77%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 3.77%
Vitamin B12 Deficiency: 2 people, 3.77%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 3.77%
High Blood Pressure: 2 people, 3.77%
Biotin Deficiency: 2 people, 3.77%
Rickets (softening of bones): 2 people, 3.77%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol and have Vaginal discharge?

- Check whether Vaginal discharge is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol:

Estradiol (18,986 reports)

Browse all side effects of Estradiol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal discharge:

Vaginal discharge (647 drugs)

Browse all the conditions that are associated with Vaginal discharge:

Vaginal discharge (1,199 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estradiol) and Estradiol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.