Ethosuximide and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Ethosuximide (ethosuximide), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Levetiracetam, and have Seizures.

The phase IV clinical study analyzes which people have Headache when taking Ethosuximide. It is created by eHealthMe based on reports of 1,763 people who have side effects when taking Ethosuximide from the FDA, and is updated regularly.

What is Ethosuximide?

Ethosuximide has active ingredients of ethosuximide. It is often used in epilepsy. eHealthMe is studying from 1,798 Ethosuximide users. Check the latest studies of Ethosuximide.

What is Headache?

Headache (pain in head) is found to be associated with 3,757 drugs and 5,776 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 12, 2026

1,763 people reported to have side effects when taking Ethosuximide.
Among them, 51 people (2.89%) have Headache.

Among these 51 people:

How long have people been on Ethosuximide when they have Headache? *

What is the gender of people who have Headache when taking Ethosuximide? *

female: 70.83 %
male: 29.17 %

What is the age of people who have Headache when taking Ethosuximide? *

What are other drugs people take besides Ethosuximide? *

What are other side effects people have besides Headache? *

Loss Of Consciousness: 11 people, 21.57%
Irritability: 11 people, 21.57%
Weight Increased: 10 people, 19.61%
Drug Ineffective: 9 people, 17.65%
Drug Resistance (reduction in effectiveness of a drug): 9 people, 17.65%
Nausea (feeling of having an urge to vomit): 8 people, 15.69%
Dizziness: 8 people, 15.69%
Nausea And Vomiting: 7 people, 13.73%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 13.73%
Psychotic Disorder: 7 people, 13.73%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 12 people, 23.53%
Melas Syndrome (melas (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is a progressive neurodegenerative disorder): 4 people, 7.84%
Mood Swings (an extreme or rapid change in mood): 2 people, 3.92%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 3.92%
Sleep Disorder: 1 person, 1.96%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 1.96%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 1 person, 1.96%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 1 person, 1.96%
Consciousness Fluctuating: 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Ethosuximide and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ethosuximide:

Ethosuximide (1,798 reports)

Headache treatments and more:

Headache (756,645 reports)

Browse all side effects of Ethosuximide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,757 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethosuximide (the active ingredients of Ethosuximide) and Ethosuximide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.