Excedrin and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 20-29 old, also take Nuvaring, and have Birth control.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,739 Excedrin users. Check the latest studies of Excedrin.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 421 drugs and 533 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On Jan, 14, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 17 people (0.08%) have Hypercoagulation.

Among these 17 people:

What is the gender of people who have Hypercoagulation when taking Excedrin? *

female: 100 %
male: 0.0 %

What is the age of people who have Hypercoagulation when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Hypercoagulation? *

Pulmonary Embolism (blockage of the main artery of the lung): 11 people, 64.71%
Abdominal Pain: 10 people, 58.82%
Nausea (feeling of having an urge to vomit): 9 people, 52.94%
Depression: 8 people, 47.06%
Constipation: 6 people, 35.29%
Cough: 6 people, 35.29%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 29.41%
Weakness: 5 people, 29.41%
International Normalised Ratio Increased: 5 people, 29.41%
Drug Hypersensitivity: 5 people, 29.41%

What are the existing conditions these people have? *

Birth Control: 8 people, 47.06%
Rhinorrhea (watery mucus discharge from the nose): 3 people, 17.65%
Cough: 3 people, 17.65%
Chest Pain: 3 people, 17.65%
Type 2 Diabetes: 1 person, 5.88%
Menstruation Irregular: 1 person, 5.88%
Left Ventricular Dysfunction: 1 person, 5.88%
Irritable Bowel Syndrome: 1 person, 5.88%
Heavy Or Prolong Menstrual Bleeding: 1 person, 5.88%
Heart Rate Irregular: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Hypercoagulation?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,739 reports)

Hypercoagulation treatments and more:

Hypercoagulation (4,011 reports)

How severe was Hypercoagulation and when was it recovered:

Hypercoagulation in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Hypercoagulation and drugs with ingredients of acetaminophen; aspirin; caffeine

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (421 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (533 conditions)

Drugs similar to Excedrin and Hypercoagulation :

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.