Femara and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Femara (letrozole), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Zoloft, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Femara. It is created by eHealthMe based on reports of 19,093 people who have side effects when taking Femara from the FDA, and is updated regularly.

What is Femara?

Femara has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 19,630 Femara users. Check the latest studies of Femara.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,096 drugs and 1,565 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

On Jul, 06, 2026

19,093 people reported to have side effects when taking Femara.
Among them, 14 people (0.07%) have Interstitial nephritis.

Could Femara cause Interstitial nephritis?

Among these 14 people:

How long have people been on Femara when they have Interstitial nephritis? *

What is the gender of people who have Interstitial nephritis when taking Femara? *

female: 100 %
male: 0.0 %

What is the age of people who have Interstitial nephritis when taking Femara? *

What are other drugs people take besides Femara? *

What are other side effects people have besides Interstitial nephritis? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 71.43%
Pain: 9 people, 64.29%
Diarrhea: 9 people, 64.29%
Hypotension (abnormally low blood pressure): 8 people, 57.14%
Rashes (redness): 8 people, 57.14%
Osteomyelitis (infection of bone): 7 people, 50.00%
Burning Sensation: 7 people, 50.00%
Bone Disorder: 7 people, 50.00%
Bone Formation Increased: 7 people, 50.00%
Disease Progression: 7 people, 50.00%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 50.00%
Depression: 7 people, 50.00%
Cystitis Interstitial (unknown cause characterized by bladder pain): 7 people, 50.00%
Breast Cancer Metastatic: 7 people, 50.00%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 6 people, 42.86%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%
Headache (pain in head): 2 people, 14.29%
Pain: 1 person, 7.14%
Liver Disorder (liver diseases): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Femara and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Femara:

Femara (19,630 reports)

Browse all side effects of Femara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Interstitial nephritis (1,096 drugs)

Browse all the conditions that are associated with Interstitial nephritis:

Interstitial nephritis (1,565 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on letrozole (the active ingredients of Femara) and Femara (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.