Flonase and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Flonase (fluticasone propionate), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Zofran, and have Osteoporosis.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Flonase. It is created by eHealthMe based on reports of 73,331 people who have side effects when taking Flonase from the FDA, and is updated regularly.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 966 drugs and 1,094 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

73,331 people reported to have side effects when taking Flonase.
Among them, 83 people (0.11%) have Adrenal insufficiency.

Could Flonase cause Adrenal insufficiency?

Among these 83 people:

How long have people been on Flonase when they have Adrenal insufficiency? *

What is the gender of people who have Adrenal insufficiency when taking Flonase? *

female: 80.26 %
male: 19.74 %

What is the age of people who have Adrenal insufficiency when taking Flonase? *

What are other drugs people take besides Flonase? *

What are other side effects people have besides Adrenal insufficiency? *

Fatigue (feeling of tiredness): 27 people, 32.53%
Diarrhea: 22 people, 26.51%
Hypotension (abnormally low blood pressure): 21 people, 25.30%
Nausea (feeling of having an urge to vomit): 20 people, 24.10%
Pain: 20 people, 24.10%
Asthma: 17 people, 20.48%
Sepsis (a severe blood infection that can lead to organ failure and death): 17 people, 20.48%
Pneumonia: 16 people, 19.28%
Acute Kidney Failure: 16 people, 19.28%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 18.07%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 16.87%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 11 people, 13.25%
Thrombocytopenia (decrease of platelets in blood): 10 people, 12.05%
Asthma: 10 people, 12.05%
Hypersensitivity: 7 people, 8.43%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 7.23%
High Blood Pressure: 6 people, 7.23%
High Blood Cholesterol: 5 people, 6.02%
Cough: 5 people, 6.02%
Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 4 people, 4.82%

* Approximation only. Some reports may have incomplete information.

Do you take Flonase and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flonase:

Flonase (75,441 reports)

Browse all side effects of Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (966 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,094 conditions)

Related publications that referenced our studies

Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .
Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on fluticasone propionate (the active ingredients of Flonase) and Flonase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.