Flonase and Granulomatous liver disease - a phase IV clinical study of FDA data

Summary:

Granulomatous liver disease is reported as a side effect among people who take Flonase (fluticasone propionate), especially for people who are female, 60+ old, also take Effexor, and have Calcium deficiency.

The phase IV clinical study analyzes which people have Granulomatous liver disease when taking Flonase. It is created by eHealthMe based on reports of 73,331 people who have side effects when taking Flonase from the FDA, and is updated regularly.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

What is Granulomatous liver disease?

Granulomatous liver disease (a mass of inflamed granulation tissue of liver) is found to be associated with 155 drugs and 284 conditions by eHealthMe. Check the latest studies of Granulomatous liver disease.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

73,331 people reported to have side effects when taking Flonase.
Among them, 23 people (0.03%) have Granulomatous liver disease.

Could Flonase cause Granulomatous liver disease?

Among these 23 people:

What is the gender of people who have Granulomatous liver disease when taking Flonase? *

female: 95.65 %
male: 4.35 %

What is the age of people who have Granulomatous liver disease when taking Flonase? *

What are other drugs people take besides Flonase? *

What are other side effects people have besides Granulomatous liver disease? *

Injury: 19 people, 82.61%
Tooth Fracture: 19 people, 82.61%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 19 people, 82.61%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 19 people, 82.61%
Spinal Osteoarthritis (joint cartilage loss in spine): 19 people, 82.61%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 82.61%
Stress And Anxiety: 19 people, 82.61%
Pain In Jaw: 19 people, 82.61%
Pain: 19 people, 82.61%
Tooth Loss: 19 people, 82.61%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 9 people, 39.13%
Metastases To Spine (cancer spreads to spine): 9 people, 39.13%
Calcium Deficiency (lack of calcium): 9 people, 39.13%
Lung Neoplasm (tumour of lung): 8 people, 34.78%
Upper Respiratory Tract Infection: 4 people, 17.39%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 8.70%
Metastases To Bone (cancer spreads to bone): 2 people, 8.70%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 8.70%
Breast Cancer: 2 people, 8.70%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Flonase and have Granulomatous liver disease?

- Check whether Granulomatous liver disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flonase:

Flonase (75,441 reports)

Browse all side effects of Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Granulomatous liver disease:

Granulomatous liver disease (155 drugs)

Browse all the conditions that are associated with Granulomatous liver disease:

Granulomatous liver disease (284 conditions)

Related publications that referenced our studies

Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .
Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on fluticasone propionate (the active ingredients of Flonase) and Flonase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.