Fosamax and Aortic dilatation - a phase IV clinical study of FDA data

Summary:

Aortic dilatation is found among people who take Fosamax, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Fosamax and have Aortic dilatation. It is created by eHealthMe based on reports of 98,641 people who have side effects when taking Fosamax from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

98,641 people reported to have side effects when taking Fosamax.
Among them, 85 people (0.09%) have Aortic dilatation.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 99,623 Fosamax users for its effectiveness, alternative drugs and more.

What is Aortic dilatation?

Aortic dilatation is found to be associated with 741 drugs and 381 conditions by eHealthMe.

Number of Fosamax and Aortic dilatation reports submitted per year:

Time on Fosamax when people have Aortic dilatation *:

Gender of people who have Aortic dilatation when taking Fosamax *:

female: 70.51 %
male: 29.49 %

Age of people who have Aortic dilatation when taking Fosamax *:

Common drugs people take besides Fosamax *:

Common side effects people have besides Aortic dilatation *:

Fall: 67 people, 78.82%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 63 people, 74.12%
Back Pain: 50 people, 58.82%
Joint Pain: 49 people, 57.65%
Femur Fracture: 42 people, 49.41%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 42 people, 49.41%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 41 people, 48.24%
Intervertebral Disc Degeneration (spinal disc degeneration): 36 people, 42.35%
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 35 people, 41.18%
Enlarged Heart: 34 people, 40.00%

Common conditions people have *:

High Blood Pressure: 14 people, 16.47%
Asthma: 12 people, 14.12%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 7.06%
Type 2 Diabetes: 3 people, 3.53%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 3.53%
Prostate Cancer: 3 people, 3.53%
Breast Cancer: 3 people, 3.53%
Irritable Bowel Syndrome: 2 people, 2.35%
Breast Cancer Metastatic: 2 people, 2.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 2.35%

* Approximation only. Some reports may have incomplete information.

Do you take Fosamax and have Aortic dilatation?

Check whether Aortic dilatation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

Related studies

How severe was Aortic dilatation and when was it recovered:

Aortic dilatation in Fosamax

Expand to all the drugs that have ingredients of alendronate sodium:

Aortic dilatation and drugs with ingredients of alendronate sodium

Alternative drugs to, pros and cons of Fosamax:

Fosamax (99,623 reports)

Common Fosamax side effects:

Pain: 12,372 reports
Joint pain: 10,835 reports
Fatigue (feeling of tiredness): 10,750 reports
High blood pressure: 10,439 reports
Stress and anxiety: 9,609 reports

Browse all side effects of Fosamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Aortic dilatation treatments and more:

Aortic dilatation (1,293 reports)

COVID vaccines that are related to Aortic dilatation:

Common drugs associated with Aortic dilatation:

Aspirin: 148 reports
Zometa: 107 reports

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium (the active ingredients of Fosamax) and Fosamax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.