Fosamax and Poor peripheral circulation - a phase IV clinical study of FDA data

Summary:

Poor peripheral circulation is reported as a side effect among people who take Fosamax (alendronate sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Alendronate Sodium, and have High blood pressure.

The phase IV clinical study analyzes which people have Poor peripheral circulation when taking Fosamax. It is created by eHealthMe based on reports of 104,411 people who have side effects when taking Fosamax from the FDA, and is updated regularly.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.

What is Poor peripheral circulation?

Poor peripheral circulation is found to be associated with 532 drugs and 695 conditions by eHealthMe. Check the latest studies of Poor peripheral circulation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

104,411 people reported to have side effects when taking Fosamax.
Among them, 32 people (0.03%) have Poor peripheral circulation.

Could Fosamax cause Poor peripheral circulation?

Among these 32 people:

How long have people been on Fosamax when they have Poor peripheral circulation? *

What is the gender of people who have Poor peripheral circulation when taking Fosamax? *

female: 93.55 %
male: 6.45 %

What is the age of people who have Poor peripheral circulation when taking Fosamax? *

What are other drugs people take besides Fosamax? *

What are other side effects people have besides Poor peripheral circulation? *

Fall: 24 people, 75.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 22 people, 68.75%
Femur Fracture: 17 people, 53.12%
Joint Pain: 17 people, 53.12%
Back Pain: 17 people, 53.12%
Impaired Healing: 16 people, 50.00%
Diarrhea: 15 people, 46.88%
Stress And Anxiety: 15 people, 46.88%
Pain In Extremity: 14 people, 43.75%
Eye Disorder: 14 people, 43.75%

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.50%
High Blood Cholesterol: 2 people, 6.25%
Depression: 2 people, 6.25%
Stable Angina (a constant chest pain): 1 person, 3.12%
Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 3.12%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.12%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 3.12%
Diabetes: 1 person, 3.12%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Fosamax and have Poor peripheral circulation?

- Check whether Poor peripheral circulation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fosamax:

Fosamax (105,452 reports)

Browse all side effects of Fosamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Poor peripheral circulation:

Poor peripheral circulation (532 drugs)

Browse all the conditions that are associated with Poor peripheral circulation:

Poor peripheral circulation (695 conditions)

Related publications that referenced our studies

Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .
Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium (the active ingredients of Fosamax) and Fosamax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.