Furosemide and Kounis syndrome - a phase IV clinical study of FDA data

Summary:

Kounis syndrome is reported as a side effect among people who take Furosemide (furosemide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Clopidogrel, and have Pneumonia.

The phase IV clinical study analyzes which people have Kounis syndrome when taking Furosemide. It is created by eHealthMe based on reports of 313,719 people who have side effects when taking Furosemide from the FDA, and is updated regularly.

What is Furosemide?

Furosemide has active ingredients of furosemide. It is often used in fluid retention. eHealthMe is studying from 316,095 Furosemide users. Check the latest studies of Furosemide.

What is Kounis syndrome?

Kounis syndrome (the concurrence of heart pain with conditions associated with mast cell activation leads to heart muscle damage) is found to be associated with 122 drugs and 203 conditions by eHealthMe. Check the latest studies of Kounis syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

313,719 people reported to have side effects when taking Furosemide.
Among them, 30 people (0.01%) have Kounis syndrome.

Among these 30 people:

How long have people been on Furosemide when they have Kounis syndrome? *

What is the gender of people who have Kounis syndrome when taking Furosemide? *

female: 26.92 %
male: 73.08 %

What is the age of people who have Kounis syndrome when taking Furosemide? *

What are other drugs people take besides Furosemide? *

What are other side effects people have besides Kounis syndrome? *

Erythema Multiforme (a type of hypersensitivity reaction): 9 people, 30.00%
Pneumonia: 7 people, 23.33%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 7 people, 23.33%
Hypotension (abnormally low blood pressure): 6 people, 20.00%
Arrhythmias (irregular heartbeat): 5 people, 16.67%
Breathing - Slowed Or Stopped: 5 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 16.67%
Rash Erythematous (redness of the skin): 5 people, 16.67%
Itching: 4 people, 13.33%
High Blood Cholesterol: 3 people, 10.00%

What are the existing conditions these people have? *

Pneumonia: 13 people, 43.33%
Blood Uric Acid Increased: 8 people, 26.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 20.00%
Type 2 Diabetes: 4 people, 13.33%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 6.67%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 1 person, 3.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.33%
Neuromuscular Blockade: 1 person, 3.33%
Menstruation Irregular: 1 person, 3.33%
Cough: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Furosemide and have Kounis syndrome?

- Check whether Kounis syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Furosemide:

Furosemide (316,095 reports)

Kounis syndrome treatments and more:

Kounis syndrome (2,190 reports)

Browse all side effects of Furosemide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Kounis syndrome:

Kounis syndrome (122 drugs)

Browse all the conditions that are associated with Kounis syndrome:

Kounis syndrome (203 conditions)

Related publications that referenced our studies

Ochoa PS, Fisher T, "A 7‐Year Case of Furosemide‐Induced Immune Thrombocytopenia", Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2013 Jul .
Ochoa PS, Fisher T, "A 7‐Year Case of Furosemide‐Induced Immune Thrombocytopenia", Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2013 Jul .

How the study uses the data?

The study uses data from the FDA. It is based on furosemide (the active ingredients of Furosemide) and Furosemide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.