Glucophage and Concomitant disease progression - a phase IV clinical study of FDA data

Summary:

Concomitant disease progression is reported as a side effect among people who take Glucophage (metformin hydrochloride), especially for people who are male, 60+ old, also take Amaryl, and have High blood pressure.

The phase IV clinical study analyzes which people have Concomitant disease progression when taking Glucophage. It is created by eHealthMe based on reports of 59,839 people who have side effects when taking Glucophage from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Concomitant disease progression?

Concomitant disease progression (progress in accompanying disease) is found to be associated with 372 drugs and 622 conditions by eHealthMe. Check the latest studies of Concomitant disease progression.

On Jul, 12, 2026

59,839 people reported to have side effects when taking Glucophage.
Among them, 27 people (0.05%) have Concomitant disease progression.

Could Glucophage cause Concomitant disease progression?

Among these 27 people:

What is the gender of people who have Concomitant disease progression when taking Glucophage? *

female: 29.63 %
male: 70.37 %

What is the age of people who have Concomitant disease progression when taking Glucophage? *

What are other drugs people take besides Glucophage? *

What are other side effects people have besides Concomitant disease progression? *

Hypovolaemia (a decreased volume of circulating blood in the body): 15 people, 55.56%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 13 people, 48.15%
Dizziness: 12 people, 44.44%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 12 people, 44.44%
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest)): 7 people, 25.93%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 6 people, 22.22%
Blood Urea Increased: 6 people, 22.22%
Abdominal Pain: 6 people, 22.22%
Abdominal Pain Upper: 6 people, 22.22%
Fatigue (feeling of tiredness): 6 people, 22.22%

What are the existing conditions these people have? *

High Blood Pressure: 19 people, 70.37%
Insomnia (sleeplessness): 13 people, 48.15%
Cardiac Failure Chronic: 12 people, 44.44%
Hyperlipidaemia (presence of excess lipids in the blood): 12 people, 44.44%
Cardiac Failure Congestive: 12 people, 44.44%
Cough: 12 people, 44.44%
Enlarged Prostate: 12 people, 44.44%
Constipation: 6 people, 22.22%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 6 people, 22.22%
Fluid Retention (an abnormal accumulation of fluid in the blood): 6 people, 22.22%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage and have Concomitant disease progression?

- Check whether Concomitant disease progression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucophage:

Glucophage (60,851 reports)

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Concomitant disease progression:

Concomitant disease progression (372 drugs)

Browse all the conditions that are associated with Concomitant disease progression:

Concomitant disease progression (622 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage) and Glucophage (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.