Glucophage and Umbilical hernia - a phase IV clinical study of FDA data

Summary:

Umbilical hernia is reported as a side effect among people who take Glucophage (metformin hydrochloride), especially for people who are female, 60+ old, also take Amaryl, and have High blood pressure.

The phase IV clinical study analyzes which people have Umbilical hernia when taking Glucophage. It is created by eHealthMe based on reports of 59,839 people who have side effects when taking Glucophage from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Umbilical hernia?

Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button) is found to be associated with 644 drugs and 676 conditions by eHealthMe. Check the latest studies of Umbilical hernia.

On Jul, 15, 2026

59,839 people reported to have side effects when taking Glucophage.
Among them, 42 people (0.07%) have Umbilical hernia.

Could Glucophage cause Umbilical hernia?

Among these 42 people:

What is the gender of people who have Umbilical hernia when taking Glucophage? *

female: 60 %
male: 40 %

What is the age of people who have Umbilical hernia when taking Glucophage? *

What are other drugs people take besides Glucophage? *

What are other side effects people have besides Umbilical hernia? *

Nausea (feeling of having an urge to vomit): 17 people, 40.48%
Gallstones (stone formation by bile component): 12 people, 28.57%
Dyspnea (difficult or laboured breathing): 10 people, 23.81%
Oedema Peripheral (superficial swelling): 10 people, 23.81%
High Blood Pressure: 9 people, 21.43%
Nausea And Vomiting: 8 people, 19.05%
Fatigue (feeling of tiredness): 8 people, 19.05%
Joint Pain: 7 people, 16.67%
Hypokalemia (low potassium): 7 people, 16.67%
Ascites (accumulation of fluid in the abdominal cavity): 7 people, 16.67%

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 28.57%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 9.52%
Pain: 3 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.14%
Bleeding Disorders: 2 people, 4.76%
Cardiac Disorder: 2 people, 4.76%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 4.76%
Gout (uric acid crystals building up in the body): 2 people, 4.76%
Growth Hormone Deficiency: 2 people, 4.76%
Cardiac Failure: 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage and have Umbilical hernia?

- Check whether Umbilical hernia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucophage:

Glucophage (60,851 reports)

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Umbilical hernia:

Umbilical hernia (644 drugs)

Browse all the conditions that are associated with Umbilical hernia:

Umbilical hernia (676 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage) and Glucophage (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.