Guaifenesin and Lactic acidosis - a phase IV clinical study of FDA data

Summary:

Lactic acidosis is reported as a side effect among people who take Guaifenesin (guaifenesin), especially for people who are male, 60+ old, also take Aspirin, and have Pain.

The phase IV clinical study analyzes which people have Lactic acidosis when taking Guaifenesin. It is created by eHealthMe based on reports of 11,942 people who have side effects when taking Guaifenesin from the FDA, and is updated regularly.

What is Guaifenesin?

Guaifenesin has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 12,106 Guaifenesin users. Check the latest studies of Guaifenesin.

What is Lactic acidosis?

Lactic acidosis (low ph in body tissues) is found to be associated with 994 drugs and 1,277 conditions by eHealthMe. Check the latest studies of Lactic acidosis.

On Jul, 19, 2026

11,942 people reported to have side effects when taking Guaifenesin.
Among them, 22 people (0.18%) have Lactic acidosis.

Could Guaifenesin cause Lactic acidosis?

Among these 22 people:

What is the gender of people who have Lactic acidosis when taking Guaifenesin? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Lactic acidosis when taking Guaifenesin? *

What are other drugs people take besides Guaifenesin? *

What are other side effects people have besides Lactic acidosis? *

Thrombocytopenia (decrease of platelets in blood): 9 people, 40.91%
Pneumonia: 8 people, 36.36%
Hypotension (abnormally low blood pressure): 7 people, 31.82%
Atrial Thrombosis (blood clot that develops in an artery): 7 people, 31.82%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 27.27%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 22.73%
Mitral Valve Incompetence (inefficient heart valve): 5 people, 22.73%
Rashes (redness): 5 people, 22.73%
Hyperkalemia (damage to or disease of the kidney): 5 people, 22.73%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 22.73%

What are the existing conditions these people have? *

Pain: 6 people, 27.27%
Dyspnea (difficult or laboured breathing): 5 people, 22.73%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 22.73%
Bladder Spasm: 4 people, 18.18%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 4 people, 18.18%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 4 people, 18.18%
Nausea (feeling of having an urge to vomit): 4 people, 18.18%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 18.18%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 18.18%
Type 2 Diabetes: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Guaifenesin and have Lactic acidosis?

- Check whether Lactic acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Guaifenesin:

Guaifenesin (12,106 reports)

Lactic acidosis treatments and more:

Lactic acidosis (34,314 reports)

Browse all side effects of Guaifenesin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lactic acidosis:

Lactic acidosis (994 drugs)

Browse all the conditions that are associated with Lactic acidosis:

Lactic acidosis (1,277 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on guaifenesin (the active ingredients of Guaifenesin) and Guaifenesin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.