Guanfacine hydrochloride and Aggression - a phase IV clinical study of FDA data

Summary:

Aggression is reported as a side effect among people who take Guanfacine hydrochloride (guanfacine hydrochloride), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Valproic Acid, and have Allergic rhinitis.

The phase IV clinical study analyzes which people have Aggression when taking Guanfacine hydrochloride. It is created by eHealthMe based on reports of 861 people who have side effects when taking Guanfacine hydrochloride from the FDA, and is updated regularly.

What is Guanfacine hydrochloride?

Guanfacine hydrochloride has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,216 Guanfacine hydrochloride users. Check the latest studies of Guanfacine hydrochloride.

What is Aggression?

Aggression is found to be associated with 1,523 drugs and 1,965 conditions by eHealthMe. Check the latest studies of Aggression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

861 people reported to have side effects when taking Guanfacine hydrochloride.
Among them, 46 people (5.34%) have Aggression.

Could Guanfacine hydrochloride cause Aggression?

Among these 46 people:

How long have people been on Guanfacine hydrochloride when they have Aggression? *

What is the gender of people who have Aggression when taking Guanfacine hydrochloride? *

female: 21.43 %
male: 78.57 %

What is the age of people who have Aggression when taking Guanfacine hydrochloride? *

What are other drugs people take besides Guanfacine hydrochloride? *

What are other side effects people have besides Aggression? *

Agitation (state of anxiety or nervous excitement): 19 people, 41.30%
Drug Ineffective: 11 people, 23.91%
Abnormal Behavior: 9 people, 19.57%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 13.04%
Insomnia (sleeplessness): 6 people, 13.04%
Weight Increased: 5 people, 10.87%
Hyperammonaemia: 4 people, 8.70%
Crying: 4 people, 8.70%
Irritability: 4 people, 8.70%
Tardive Dyskinesia (a disorder that involves involuntary movements): 4 people, 8.70%

What are the existing conditions these people have? *

Allergic Rhinitis: 5 people, 10.87%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 6.52%
Sedation: 3 people, 6.52%
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts): 3 people, 6.52%
Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 3 people, 6.52%
Affective Disorder (mental disorder): 3 people, 6.52%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 4.35%
Hypotonia (low muscle tone): 2 people, 4.35%
Bipolar Disorder (mood disorder): 2 people, 4.35%
Agitation (state of anxiety or nervous excitement): 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Guanfacine hydrochloride and have Aggression?

- Check whether Aggression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Guanfacine hydrochloride:

Guanfacine hydrochloride (1,216 reports)

Aggression treatments and more:

Aggression (65,312 reports)

Browse all side effects of Guanfacine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aggression:

Aggression (1,523 drugs)

Browse all the conditions that are associated with Aggression:

Aggression (1,965 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on guanfacine hydrochloride (the active ingredients of Guanfacine hydrochloride) and Guanfacine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.