Hydrocodone and Ankylosing spondylitis - a phase IV clinical study of FDA data

Summary:

Ankylosing spondylitis is reported as a side effect among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen), especially for people who are female, 60+ old, also take Omeprazole, and have Pain.

The phase IV clinical study analyzes which people have Ankylosing spondylitis when taking Hydrocodone. It is created by eHealthMe based on reports of 13,053 people who have side effects when taking Hydrocodone from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Ankylosing spondylitis?

Ankylosing spondylitis (type of arthritis affecting the spine) is found to be associated with 739 drugs and 1,051 conditions by eHealthMe. Check the latest studies of Ankylosing spondylitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

13,053 people reported to have side effects when taking Hydrocodone.
Among them, 14 people (0.11%) have Ankylosing spondylitis.

Could Hydrocodone cause Ankylosing spondylitis?

Among these 14 people:

What is the gender of people who have Ankylosing spondylitis when taking Hydrocodone? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Ankylosing spondylitis when taking Hydrocodone? *

What are other drugs people take besides Hydrocodone? *

Ibuprofen: 4 people, 28.57%
Prednisone: 4 people, 28.57%
Vitamin D3: 4 people, 28.57%
Omeprazole: 4 people, 28.57%
Hydrocodone Bitartrate And Acetaminophen: 3 people, 21.43%
Loratadine: 3 people, 21.43%
Maxalt: 3 people, 21.43%
Folic Acid: 3 people, 21.43%
Methotrexate: 3 people, 21.43%
Nuvigil: 3 people, 21.43%

What are other side effects people have besides Ankylosing spondylitis? *

Weight Decreased: 5 people, 35.71%
Weakness: 5 people, 35.71%
Fatigue (feeling of tiredness): 4 people, 28.57%
Joint Pain: 4 people, 28.57%
Intervertebral Disc Protrusion (spinal disc protrusion): 4 people, 28.57%
High Blood Pressure: 4 people, 28.57%
Depressed Mood: 4 people, 28.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 28.57%
Drug Ineffective: 3 people, 21.43%
Haemangioma Of Liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver): 3 people, 21.43%

What are the existing conditions these people have? *

Pain: 6 people, 42.86%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 35.71%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 28.57%
Drowsiness: 3 people, 21.43%
Nausea And Vomiting: 3 people, 21.43%
High Blood Pressure: 2 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Swelling: 1 person, 7.14%
Depression: 1 person, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone and have Ankylosing spondylitis?

- Check whether Ankylosing spondylitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone:

Hydrocodone (13,115 reports)

Ankylosing spondylitis treatments and more:

Ankylosing spondylitis (130,235 reports)

How severe was Ankylosing spondylitis and when was it recovered:

Ankylosing spondylitis in Hydrocodone

Expand to all the drugs that have ingredients of hydrocodone bitartrate; ibuprofen:

Ankylosing spondylitis and drugs with ingredients of hydrocodone bitartrate; ibuprofen

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate; ibuprofen (the active ingredients of Hydrocodone) and Hydrocodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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