Hydroxyzine and Bipolar i disorder - a phase IV clinical study of FDA data

Summary:

Bipolar i disorder is reported as a side effect among people who take Hydroxyzine (hydroxyzine hydrochloride), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Abilify, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Bipolar i disorder when taking Hydroxyzine. It is created by eHealthMe based on reports of 51,890 people who have side effects when taking Hydroxyzine from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Bipolar i disorder?

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode) is found to be associated with 380 drugs and 831 conditions by eHealthMe. Check the latest studies of Bipolar i disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

51,890 people reported to have side effects when taking Hydroxyzine.
Among them, 25 people (0.05%) have Bipolar i disorder.

Could Hydroxyzine cause Bipolar i disorder?

Among these 25 people:

How long have people been on Hydroxyzine when they have Bipolar i disorder? *

What is the gender of people who have Bipolar i disorder when taking Hydroxyzine? *

female: 75 %
male: 25 %

What is the age of people who have Bipolar i disorder when taking Hydroxyzine? *

What are other drugs people take besides Hydroxyzine? *

What are other side effects people have besides Bipolar i disorder? *

Mania (a state of abnormally elevated or irritable mood): 8 people, 32.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 32.00%
Bipolar Disorder (mood disorder): 8 people, 32.00%
Suicidal Ideation: 8 people, 32.00%
Loss Of Consciousness: 4 people, 16.00%
Back Pain: 4 people, 16.00%
Initial Insomnia (feeling of inadequate or poor-quality sleep): 4 people, 16.00%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 4 people, 16.00%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 4 people, 16.00%
Delusion (a false belief or opinion): 4 people, 16.00%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 9 people, 36.00%
High Blood Pressure: 7 people, 28.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 24.00%
Pain: 6 people, 24.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 16.00%
Sleep Disorder: 4 people, 16.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 16.00%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 4 people, 16.00%
Depression: 3 people, 12.00%
Diarrhea: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyzine and have Bipolar i disorder?

- Check whether Bipolar i disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyzine:

Hydroxyzine (54,070 reports)

Browse all side effects of Hydroxyzine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar i disorder:

Bipolar i disorder (380 drugs)

Browse all the conditions that are associated with Bipolar i disorder:

Bipolar i disorder (831 conditions)

Related publications that referenced our studies

Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .
Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride (the active ingredients of Hydroxyzine) and Hydroxyzine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.