Ibrance and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Ibrance (palbociclib), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Letrozole, and have Breast cancer female.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Ibrance. It is created by eHealthMe based on reports of 104,340 people who have side effects when taking Ibrance from the FDA, and is updated regularly.

What is Ibrance?

Ibrance has active ingredients of palbociclib. eHealthMe is studying from 104,433 Ibrance users. Check the latest studies of Ibrance.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 979 drugs and 1,212 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Nov, 02, 2025

104,340 people reported to have side effects when taking Ibrance.
Among them, 64 people (0.06%) have Knee joint replacement.

Could Ibrance cause Knee joint replacement?

Among these 64 people:

How long have people been on Ibrance when they have Knee joint replacement? *

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What is the gender of people who have Knee joint replacement when taking Ibrance? *

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What is the age of people who have Knee joint replacement when taking Ibrance? *

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* Approximation only. Some reports may have incomplete information.

Do you take Ibrance and have Knee joint replacement?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ibrance:

Ibrance (104,433 reports)

Knee joint replacement treatments and more:

Knee joint replacement (26,754 reports)

How severe was Knee joint replacement and when was it recovered:

Knee joint replacement in Ibrance

Expand to all the drugs that have ingredients of palbociclib:

Knee joint replacement and drugs with ingredients of palbociclib (66 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Ibrance side effects:

Ibrance side effect: White blood cell count decreased (15,755 reports)
Ibrance side effect: Neoplasm progression (growth of tumour) (12,081 reports)

Browse all side effects of Ibrance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Knee joint replacement:

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (979 drugs)

Common conditions associated with Knee joint replacement:

Rheumatoid arthritis aggravated: 8,947 reports
Psoriatic arthropathy aggravated: 1,586 reports
Psoriasis: 1,549 reports
Ms: 1,416 reports
Osteoporosis: 1,015 reports
Thin bones: 978 reports
Pain: 854 reports
Alternative medicine - pain relief: 853 reports
Hypertension: 695 reports
Htn: 694 reports

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,212 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on palbociclib (the active ingredients of Ibrance) and Ibrance (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.