Ibuprofen and Neuroma - a phase IV clinical study of FDA data

Summary:

Neuroma is reported as a side effect among people who take Ibuprofen (ibuprofen), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Wellbutrin, and have High blood pressure.

The phase IV clinical study analyzes which people have Neuroma when taking Ibuprofen. It is created by eHealthMe based on reports of 239,218 people who have side effects when taking Ibuprofen from the FDA, and is updated regularly.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

What is Neuroma?

Neuroma (tumour of nerve tissue) is found to be associated with 115 drugs and 275 conditions by eHealthMe. Check the latest studies of Neuroma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 30, 2026

239,218 people reported to have side effects when taking Ibuprofen.
Among them, 44 people (0.02%) have Neuroma.

Could Ibuprofen cause Neuroma?

Among these 44 people:

How long have people been on Ibuprofen when they have Neuroma? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Neuroma when taking Ibuprofen? *

  • female: 86.36 %
  • male: 13.64 %

What is the age of people who have Neuroma when taking Ibuprofen? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 10 %
  • 30-39: 10 %
  • 40-49: 15 %
  • 50-59: 55 %
  • 60+: 10 %

What are other drugs people take besides Ibuprofen? *

  1. Wellbutrin: 21 people, 47.73%
  2. Zometa: 20 people, 45.45%
  3. Lortab: 20 people, 45.45%
  4. Aredia: 20 people, 45.45%
  5. Reglan: 19 people, 43.18%
  6. Zofran: 19 people, 43.18%
  7. Trilafon: 19 people, 43.18%
  8. Etrafon 2-25: 19 people, 43.18%
  9. Elavil: 19 people, 43.18%
  10. Ms Contin: 18 people, 40.91%

What are other side effects people have besides Neuroma? *

  1. Joint Pain: 26 people, 59.09%
  2. Insomnia (sleeplessness): 21 people, 47.73%
  3. Stress And Anxiety: 21 people, 47.73%
  4. Pain In Extremity: 21 people, 47.73%
  5. Exostosis (formation of new bone on the surface of a bone): 21 people, 47.73%
  6. Mastication Disorder (disease of chewing food): 20 people, 45.45%
  7. Injury: 20 people, 45.45%
  8. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 20 people, 45.45%
  9. Infection: 20 people, 45.45%
  10. Heavy Or Prolong Menstrual Bleeding: 20 people, 45.45%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 11.36%
  2. High Blood Pressure: 5 people, 11.36%
  3. Immune Tolerance Induction: 3 people, 6.82%
  4. Depression: 3 people, 6.82%
  5. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 3 people, 6.82%
  6. Insomnia (sleeplessness): 3 people, 6.82%
  7. Stress And Anxiety: 3 people, 6.82%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 4.55%
  9. Affective Disorder (mental disorder): 2 people, 4.55%
  10. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Ibuprofen and have Neuroma?

- Check whether Neuroma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ibuprofen:

Neuroma treatments and more:

How severe was Neuroma and when was it recovered:

Expand to all the drugs that have ingredients of ibuprofen:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neuroma:

Browse all the conditions that are associated with Neuroma:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Ibuprofen) and Ibuprofen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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