1. Home
  2. Analysis
  3. Ibuprofen
  4. Subdural-haemorrhage

Ibuprofen and Subdural haemorrhage - a phase IV clinical study of FDA data

Summary:

Subdural haemorrhage is reported as a side effect among people who take Ibuprofen (ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Xarelto, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Subdural haemorrhage when taking Ibuprofen. It is created by eHealthMe based on reports of 239,218 people who have side effects when taking Ibuprofen from the FDA, and is updated regularly.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

What is Subdural haemorrhage?

Subdural haemorrhage (bleeding between the skull and the surface of the brain) is found to be associated with 297 drugs and 456 conditions by eHealthMe. Check the latest studies of Subdural haemorrhage.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

239,218 people reported to have side effects when taking Ibuprofen.
Among them, 23 people (0.01%) have Subdural haemorrhage.

Could Ibuprofen cause Subdural haemorrhage?

Among these 23 people:

How long have people been on Ibuprofen when they have Subdural haemorrhage? *

  • < 1 month: 80 %
  • 1 - 6 months: 20 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Subdural haemorrhage when taking Ibuprofen? *

  • female: 55 %
  • male: 45 %

What is the age of people who have Subdural haemorrhage when taking Ibuprofen? *

  • 0-1: 33.33 %
  • 2-9: 5.56 %
  • 10-19: 5.56 %
  • 20-29: 5.56 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 11.11 %
  • 60+: 38.89 %

What are other drugs people take besides Ibuprofen? *

  1. Acetaminophen: 4 people, 17.39%
  2. Xarelto: 4 people, 17.39%
  3. Dexamethasone: 3 people, 13.04%
  4. Ramipril: 3 people, 13.04%
  5. Ranitidine: 3 people, 13.04%
  6. Prednisolone: 3 people, 13.04%
  7. Cimetidine: 2 people, 8.70%
  8. Dimenhydrinate: 2 people, 8.70%
  9. Fentanyl: 2 people, 8.70%
  10. Propofol: 2 people, 8.70%

What are other side effects people have besides Subdural haemorrhage? *

  1. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 39.13%
  2. Haematuria (presence of blood in urine): 7 people, 30.43%
  3. Fall: 3 people, 13.04%
  4. Cerebral Infarction (less blood supply to brain resulting tissue damage): 3 people, 13.04%
  5. Acute Myocardial Infarction (acute heart attack): 2 people, 8.70%
  6. Neutropenic Sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection): 2 people, 8.70%
  7. Injury: 2 people, 8.70%
  8. Memory Loss: 2 people, 8.70%
  9. Cerebral Haemorrhage (bleeding within the brain): 2 people, 8.70%
  10. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 8.70%

What are the existing conditions these people have? *

  1. Weight Decreased: 2 people, 8.70%
  2. High Blood Pressure: 2 people, 8.70%
  3. Thoracic Vertebral Fracture: 2 people, 8.70%
  4. Spinal Muscular Atrophy (wasting of spinal muscles): 2 people, 8.70%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 8.70%
  6. Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 8.70%
  7. Coughing Up Blood: 2 people, 8.70%
  8. Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 2 people, 8.70%
  9. Gastritis - Chronic (long lasting inflammation of stomach): 2 people, 8.70%
  10. Type 2 Diabetes: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Ibuprofen and have Subdural haemorrhage?

- Check whether Subdural haemorrhage is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ibuprofen:

Subdural haemorrhage treatments and more:

How severe was Subdural haemorrhage and when was it recovered:

Expand to all the drugs that have ingredients of ibuprofen:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Subdural haemorrhage:

Browse all the conditions that are associated with Subdural haemorrhage:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Ibuprofen) and Ibuprofen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.