Ismo and Angina pectoris aggravated - a phase IV clinical study of FDA data

Summary:

Angina pectoris aggravated is reported as a side effect among people who take Ismo (isosorbide mononitrate), especially for people who are male, 60+ old, also take Ambien, and have Pain.

The phase IV clinical study analyzes which people have Angina pectoris aggravated when taking Ismo. It is created by eHealthMe based on reports of 958 people who have side effects when taking Ismo from the FDA, and is updated regularly.

What is Ismo?

Ismo has active ingredients of isosorbide mononitrate. eHealthMe is studying from 982 Ismo users. Check the latest studies of Ismo.

What is Angina pectoris aggravated?

Angina pectoris aggravated (chest pain due to ischemia of the heart muscle) is found to be associated with 1,386 drugs and 655 conditions by eHealthMe. Check the latest studies of Angina pectoris aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

958 people reported to have side effects when taking Ismo.
Among them, 34 people (3.55%) have Angina pectoris aggravated.

Could Ismo cause Angina pectoris aggravated?

Among these 34 people:

What is the gender of people who have Angina pectoris aggravated when taking Ismo? *

female: 32.35 %
male: 67.65 %

What is the age of people who have Angina pectoris aggravated when taking Ismo? *

What are other drugs people take besides Ismo? *

What are other side effects people have besides Angina pectoris aggravated? *

Heart Attack: 16 people, 47.06%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 16 people, 47.06%
High Blood Pressure: 15 people, 44.12%
Bradycardia (abnormally slow heart action): 14 people, 41.18%
High Blood Cholesterol: 12 people, 35.29%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 32.35%
Chronic Renal Failure (kidney failure): 11 people, 32.35%
Intervertebral Disc Degeneration (spinal disc degeneration): 10 people, 29.41%
Respiratory Distress (difficulty in breathing): 10 people, 29.41%
Diverticulitis Intestinal Haemorrhagic (digestive disease which involves the formation of pouches (diverticula) within the intestinal wall with bleeding): 10 people, 29.41%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 29.41%
Pain: 10 people, 29.41%
Migraine (headache): 4 people, 11.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 8.82%
High Blood Pressure: 2 people, 5.88%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 2.94%
Diabetes: 1 person, 2.94%
Anaemia (lack of blood): 1 person, 2.94%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Ismo and have Angina pectoris aggravated?

- Check whether Angina pectoris aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ismo:

Ismo (982 reports)

Browse all side effects of Ismo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angina pectoris aggravated:

Angina pectoris aggravated (1,386 drugs)

Browse all the conditions that are associated with Angina pectoris aggravated:

Angina pectoris aggravated (655 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide mononitrate (the active ingredients of Ismo) and Ismo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.