Isoptin and Agranulocytosis - a phase IV clinical study of FDA data

Summary:

Agranulocytosis is reported as a side effect among people who take Isoptin (verapamil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people have Agranulocytosis when taking Isoptin. It is created by eHealthMe based on reports of 5,465 people who have side effects when taking Isoptin from the FDA, and is updated regularly.

What is Isoptin?

Isoptin has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 5,539 Isoptin users. Check the latest studies of Isoptin.

What is Agranulocytosis?

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection) is found to be associated with 2,327 drugs and 3,592 conditions by eHealthMe. Check the latest studies of Agranulocytosis.

On Jul, 20, 2026

5,465 people reported to have side effects when taking Isoptin.
Among them, 95 people (1.74%) have Agranulocytosis.

Among these 95 people:

How long have people been on Isoptin when they have Agranulocytosis? *

What is the gender of people who have Agranulocytosis when taking Isoptin? *

female: 65.93 %
male: 34.07 %

What is the age of people who have Agranulocytosis when taking Isoptin? *

What are other drugs people take besides Isoptin? *

Lasix: 13 people, 13.68%
Lyrica: 9 people, 9.47%
Bactrim: 9 people, 9.47%
Spironolactone: 9 people, 9.47%
Carboplatin: 9 people, 9.47%
Nexium: 8 people, 8.42%
Nebivolol Hydrochloride: 7 people, 7.37%
Furosemide: 7 people, 7.37%
Prednisolone: 7 people, 7.37%
Acetaminophen: 6 people, 6.32%

What are other side effects people have besides Agranulocytosis? *

Thrombocytopenia (decrease of platelets in blood): 33 people, 34.74%
Fever: 26 people, 27.37%
Anaemia (lack of blood): 22 people, 23.16%
Leukopenia (less number of white blood cells in blood): 19 people, 20.00%
General Physical Health Deterioration (weak health status): 11 people, 11.58%
Haemoglobin Decreased: 10 people, 10.53%
Bone Marrow Failure: 9 people, 9.47%
Metastases To Central Nervous System (cancer spreads to central nervous system): 9 people, 9.47%
Metastases To Lymph Nodes (cancer spreads to lymph node): 9 people, 9.47%
Metastases To Retroperitoneum (cancer spreads to retroperitonium): 9 people, 9.47%

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 8 people, 8.42%
Ovarian Epithelial Cancer Stage I (cancer is found in one or both of the ovaries): 7 people, 7.37%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 7.37%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 5.26%
Diabetes: 3 people, 3.16%
Pain: 3 people, 3.16%
Ovarian Cancer (cancer of ovary): 3 people, 3.16%
Urinary Tract Disorder: 3 people, 3.16%
Migraine (headache): 3 people, 3.16%
Colon Cancer: 2 people, 2.11%

* Approximation only. Some reports may have incomplete information.

Do you take Isoptin and have Agranulocytosis?

- Check whether Agranulocytosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isoptin:

Isoptin (5,539 reports)

Agranulocytosis treatments and more:

Agranulocytosis (213,267 reports)

Browse all side effects of Isoptin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agranulocytosis:

Agranulocytosis (2,327 drugs)

Browse all the conditions that are associated with Agranulocytosis:

Agranulocytosis (3,592 conditions)

Related publications that referenced our studies

Fasullo, S., Davì, S., Cosenza, G., Di Franco, F., La Manna, N., Giubilato, A., ... & Maringhini, G. , "Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature", Journal of thrombosis and thrombolysis, 2018 Jan .
Fasullo, S., Davì, S., Cosenza, G., Di Franco, F., La Manna, N., Giubilato, A., ... & Maringhini, G. , "Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature", Journal of thrombosis and thrombolysis, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on verapamil hydrochloride (the active ingredients of Isoptin) and Isoptin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.