Prempro and Oxybutynin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate) and Oxybutynin (oxybutynin). Common drug interactions include insomnia among females.

The phase IV clinical study analyzes what interactions people have when they take Prempro and Oxybutynin. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Oxybutynin?

Oxybutynin has active ingredients of oxybutynin. It is often used in urge incontinence. eHealthMe is studying from 23,143 Oxybutynin users. Check the latest studies of Oxybutynin.

On Jul, 20, 2026

43 people who take Prempro and Oxybutynin together, and have interactions are studied.

Prempro and Oxybutynin drug interactions.

What are the common drug interactions of Prempro and Oxybutynin, by gender? *:

female:

Insomnia (sleeplessness)
Chronic kidney disease
Fatigue (feeling of tiredness)
Anxiety
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Renal impairment (severely reduced kidney function)
Abdominal discomfort
Balance disorder
Blood potassium increased

male:

n/a

What are the common drug interactions of Prempro and Oxybutynin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal impairment (severely reduced kidney function)
Fatigue (feeling of tiredness)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Oral mucosal blistering (mouth ulcer)
Renal tubular necrosis (death of kidney tubules)

50-59:

Chronic kidney disease
Hypoaesthesia (reduced sense of touch or sensation)
Nephrogenic anaemia (anaemia due to kidney disease)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal failure (kidney dysfunction)
Anxiety
Balance disorder
Bladder disorder
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Contusion (a type of hematoma of tissue in which capillaries)

60+:

Insomnia (sleeplessness)
Diarrhoea
Hypertension (high blood pressure)
Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pain
Arteriosclerosis (thickening and hardening of arteries)
Blindness

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 25.58%
Pain: 10 people, 23.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 23.26%
Stress And Anxiety: 7 people, 16.28%
Depression: 7 people, 16.28%
High Blood Pressure: 7 people, 16.28%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 13.95%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 13.95%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 11.63%
Insomnia (sleeplessness): 5 people, 11.63%

* Approximation only. Some reports may have incomplete information.

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