Isotretinoin and Gastroesophageal reflux disease - a phase IV clinical study of FDA data

Summary:

Gastroesophageal reflux disease is reported as a side effect among people who take Isotretinoin (isotretinoin), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Kenalog, and have Depression.

The phase IV clinical study analyzes which people have Gastroesophageal reflux disease when taking Isotretinoin. It is created by eHealthMe based on reports of 7,967 people who have side effects when taking Isotretinoin from the FDA, and is updated regularly.

What is Isotretinoin?

Isotretinoin has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 8,155 Isotretinoin users. Check the latest studies of Isotretinoin.

What is Gastroesophageal reflux disease?

Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus) is found to be associated with 2,396 drugs and 3,490 conditions by eHealthMe. Check the latest studies of Gastroesophageal reflux disease.

On Apr, 28, 2026

7,967 people reported to have side effects when taking Isotretinoin.
Among them, 12 people (0.15%) have Gastroesophageal reflux disease.

Could Isotretinoin cause Gastroesophageal reflux disease?

Among these 12 people:

How long have people been on Isotretinoin when they have Gastroesophageal reflux disease? *

What is the gender of people who have Gastroesophageal reflux disease when taking Isotretinoin? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Gastroesophageal reflux disease when taking Isotretinoin? *

What are other drugs people take besides Isotretinoin? *

What are other side effects people have besides Gastroesophageal reflux disease? *

Stress And Anxiety: 4 people, 33.33%
Weight Loss: 2 people, 16.67%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 16.67%
Lupus-Like Syndrome (a disease symptom matches with lupus an immune disease): 2 people, 16.67%
Depression: 2 people, 16.67%
Dermoid Cyst (an abnormal growth (teratoma) containing epidermis, hair follicles, and sebaceous glands): 2 people, 16.67%
Hidradenitis (chronic disease of a type of sweat gland): 2 people, 16.67%
Weight Decreased: 2 people, 16.67%
Groin Infection (infection in groin): 2 people, 16.67%
Gastrointestinal Toxicity (damage to digestive tract by any substance): 2 people, 16.67%

What are the existing conditions these people have? *

Hidradenitis (chronic disease of a type of sweat gland): 2 people, 16.67%
Depression: 2 people, 16.67%
Sinus Disorder (disease of sinus): 1 person, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Isotretinoin and have Gastroesophageal reflux disease?

- Check whether Gastroesophageal reflux disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isotretinoin:

Isotretinoin (8,155 reports)

Browse all side effects of Isotretinoin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastroesophageal reflux disease:

Gastroesophageal reflux disease (2,396 drugs)

Browse all the conditions that are associated with Gastroesophageal reflux disease:

Gastroesophageal reflux disease (3,490 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Isotretinoin) and Isotretinoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.