Janumet xr and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Janumet xr (metformin hydrochloride; sitagliptin phosphate), especially for people who are male, 60+ old, also take Janumet, and have Dry eyes.

The phase IV clinical study analyzes which people have Stroke when taking Janumet xr. It is created by eHealthMe based on reports of 2,311 people who have side effects when taking Janumet xr from the FDA, and is updated regularly.

What is Janumet xr?

Janumet xr has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in type 2 diabetes. eHealthMe is studying from 2,357 Janumet xr users. Check the latest studies of Janumet xr.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,310 drugs and 3,035 conditions by eHealthMe. Check the latest studies of Stroke.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

2,311 people reported to have side effects when taking Janumet xr.
Among them, 14 people (0.61%) have Stroke.

Among these 14 people:

What is the gender of people who have Stroke when taking Janumet xr? *

female: 21.43 %
male: 78.57 %

What is the age of people who have Stroke when taking Janumet xr? *

What are other drugs people take besides Janumet xr? *

What are other side effects people have besides Stroke? *

Hemiparesis (weakness on one side of the body): 3 people, 21.43%
Speech Impairment (Adult) (inability to speak (adult)): 2 people, 14.29%
Swallowing Difficulty: 2 people, 14.29%
Movement - Uncoordinated: 2 people, 14.29%
Confusional State: 2 people, 14.29%
Affect Lability (emotional incontinence): 1 person, 7.14%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.14%
Abdominal Pain: 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%
Grip Strength Decreased: 1 person, 7.14%

What are the existing conditions these people have? *

High Blood Pressure: 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%
Dry Eyes (lack of adequate tears): 2 people, 14.29%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 7.14%
Testicular Failure (testicles cannot produce sperm or male hormones): 1 person, 7.14%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.14%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 7.14%
Neuralgia (pain in one or more nerves): 1 person, 7.14%
Nervousness: 1 person, 7.14%
Muscle Spasms (muscle contraction): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Janumet xr and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Janumet xr:

Janumet xr (2,357 reports)

Stroke treatments and more:

Stroke (334,635 reports)

How severe was Stroke and when was it recovered:

Stroke in Janumet xr

Expand to all the drugs that have ingredients of metformin hydrochloride; sitagliptin phosphate:

Stroke and drugs with ingredients of metformin hydrochloride; sitagliptin phosphate (201 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Janumet xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,310 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,035 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride; sitagliptin phosphate (the active ingredients of Janumet xr) and Janumet xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.