Keflex and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Keflex (cephalexin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ambien, and have Metastases to bone.

The phase IV clinical study analyzes which people have Splenomegaly when taking Keflex. It is created by eHealthMe based on reports of 14,902 people who have side effects when taking Keflex from the FDA, and is updated regularly.

What is Keflex?

Keflex has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 15,844 Keflex users. Check the latest studies of Keflex.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,121 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

On Jul, 13, 2026

14,902 people reported to have side effects when taking Keflex.
Among them, 68 people (0.46%) have Splenomegaly.

Among these 68 people:

How long have people been on Keflex when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Keflex? *

female: 56.06 %
male: 43.94 %

What is the age of people who have Splenomegaly when taking Keflex? *

What are other drugs people take besides Keflex? *

What are other side effects people have besides Splenomegaly? *

Fatigue (feeling of tiredness): 31 people, 45.59%
Dyspnea (difficult or laboured breathing): 28 people, 41.18%
Weight Decreased: 26 people, 38.24%
Nausea (feeling of having an urge to vomit): 25 people, 36.76%
Injury: 25 people, 36.76%
Pain: 25 people, 36.76%
Lung Neoplasm (tumour of lung): 23 people, 33.82%
Osteonecrosis Of Jaw (death of bone of jaw): 22 people, 32.35%
Thrombocytopenia (decrease of platelets in blood): 21 people, 30.88%
Stress And Anxiety: 21 people, 30.88%

What are the existing conditions these people have? *

Breast Cancer: 11 people, 16.18%
Metastases To Bone (cancer spreads to bone): 11 people, 16.18%
Anaemia (lack of blood): 10 people, 14.71%
Resorption Bone Increased: 8 people, 11.76%
Pain: 7 people, 10.29%
Back Pain: 6 people, 8.82%
High Blood Pressure: 6 people, 8.82%
Constipation: 5 people, 7.35%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 7.35%
High Blood Cholesterol: 5 people, 7.35%

* Approximation only. Some reports may have incomplete information.

Do you take Keflex and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keflex:

Keflex (15,844 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

Browse all side effects of Keflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,121 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

Related publications that referenced our studies

Agrawal A, Rao M, Jasdanwala S, Mathur A, Eng M, "Cephalexin Induced Cholestatic Jaundice", Case reports in gastrointestinal medicine, 2014 Aug .
Agrawal A, Rao M, Jasdanwala S, Mathur A, Eng M, "Cephalexin Induced Cholestatic Jaundice", Case reports in gastrointestinal medicine, 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on cephalexin (the active ingredients of Keflex) and Keflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.