Lacosamide and Toxic encephalopathy - a phase IV clinical study of FDA data

Summary:

Toxic encephalopathy is reported as a side effect among people who take Lacosamide (lacosamide), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Levetiracetam, and have Status epilepticus.

The phase IV clinical study analyzes which people have Toxic encephalopathy when taking Lacosamide. It is created by eHealthMe based on reports of 16,542 people who have side effects when taking Lacosamide from the FDA, and is updated regularly.

What is Lacosamide?

Lacosamide has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 16,601 Lacosamide users. Check the latest studies of Lacosamide.

What is Toxic encephalopathy?

Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances) is found to be associated with 424 drugs and 616 conditions by eHealthMe. Check the latest studies of Toxic encephalopathy.

On Jul, 08, 2026

16,542 people reported to have side effects when taking Lacosamide.
Among them, 21 people (0.13%) have Toxic encephalopathy.

Could Lacosamide cause Toxic encephalopathy?

Among these 21 people:

How long have people been on Lacosamide when they have Toxic encephalopathy? *

What is the gender of people who have Toxic encephalopathy when taking Lacosamide? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Toxic encephalopathy when taking Lacosamide? *

What are other drugs people take besides Lacosamide? *

What are other side effects people have besides Toxic encephalopathy? *

Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 8 people, 38.10%
Vision Blurred: 7 people, 33.33%
Memory Loss: 7 people, 33.33%
Loss Of Consciousness: 6 people, 28.57%
Drug Ineffective: 5 people, 23.81%
Drowsiness: 5 people, 23.81%
Numbness And Tingling (unusual prickling sensations): 4 people, 19.05%
Oxygen Saturation Decreased: 4 people, 19.05%
Retrograde Amnesia (a loss of memory-access to events that occurred, or information that was learned, before an injury or the onset of a disease): 4 people, 19.05%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 4 people, 19.05%

What are the existing conditions these people have? *

Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 6 people, 28.57%
Muscle Contracture (a permanent shortening of a muscle): 5 people, 23.81%
Back Pain: 5 people, 23.81%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 19.05%
Petit Mal Epilepsy (absence seizure): 3 people, 14.29%
Idiopathic Generalised Epilepsy (epileptic disorders that are believed to have a strong underlying genetic basis): 3 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 9.52%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.76%
Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 4.76%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Lacosamide and have Toxic encephalopathy?

- Check whether Toxic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lacosamide:

Lacosamide (16,601 reports)

Browse all side effects of Lacosamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toxic encephalopathy:

Toxic encephalopathy (424 drugs)

Browse all the conditions that are associated with Toxic encephalopathy:

Toxic encephalopathy (616 conditions)

Related publications that referenced our studies

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on lacosamide (the active ingredients of Lacosamide) and Lacosamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.