Lamictal and Cogwheel rigidity - a phase IV clinical study of FDA data

Summary:

Cogwheel rigidity is reported as a side effect among people who take Lamictal (lamotrigine), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Tegretol, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Cogwheel rigidity when taking Lamictal. It is created by eHealthMe based on reports of 74,218 people who have side effects when taking Lamictal from the FDA, and is updated regularly.

What is Lamictal?

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 82,629 Lamictal users. Check the latest studies of Lamictal.

What is Cogwheel rigidity?

Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched) is found to be associated with 156 drugs and 302 conditions by eHealthMe. Check the latest studies of Cogwheel rigidity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

74,218 people reported to have side effects when taking Lamictal.
Among them, 20 people (0.03%) have Cogwheel rigidity.

Among these 20 people:

How long have people been on Lamictal when they have Cogwheel rigidity? *

What is the gender of people who have Cogwheel rigidity when taking Lamictal? *

female: 35 %
male: 65 %

What is the age of people who have Cogwheel rigidity when taking Lamictal? *

What are other drugs people take besides Lamictal? *

Tegretol: 8 people, 40.00%
Gabitril: 7 people, 35.00%
Topamax: 7 people, 35.00%
Keppra: 7 people, 35.00%
Tasmar: 7 people, 35.00%
Neurontin: 7 people, 35.00%
Levetiracetam: 7 people, 35.00%
Carbamazepine: 5 people, 25.00%
Seroquel: 3 people, 15.00%
Carbidopa And Levodopa: 3 people, 15.00%

What are other side effects people have besides Cogwheel rigidity? *

Tremor (trembling or shaking movements in one or more parts of your body): 12 people, 60.00%
Parkinson's Disease: 11 people, 55.00%
Gait Disturbance: 10 people, 50.00%
Depression: 10 people, 50.00%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 40.00%
Speech Impairment (Adult) (inability to speak (adult)): 8 people, 40.00%
Fatigue (feeling of tiredness): 8 people, 40.00%
Muscle Aches (muscle pain): 8 people, 40.00%
Electroencephalogram Abnormal: 8 people, 40.00%
Dyskinesia (abnormality or impairment of voluntary movement): 8 people, 40.00%

What are the existing conditions these people have? *

Parkinson's Disease: 2 people, 10.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 5.00%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 5.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 5.00%
Anger: 1 person, 5.00%
Abnormal Behavior: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Lamictal and have Cogwheel rigidity?

- Check whether Cogwheel rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamictal:

Lamictal (82,629 reports)

Browse all side effects of Lamictal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cogwheel rigidity:

Cogwheel rigidity (156 drugs)

Browse all the conditions that are associated with Cogwheel rigidity:

Cogwheel rigidity (302 conditions)

Related publications that referenced our studies

Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .
Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamictal) and Lamictal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.