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Lamotrigine and Neurological decompensation - a phase IV clinical study of FDA data

Summary:

Neurological decompensation is reported as a side effect among people who take Lamotrigine (lamotrigine), especially for people who are male, 20-29 old, have been taking the drug for < 1 month also take Levetiracetam, and have Appetite - decreased.

The phase IV clinical study analyzes which people have Neurological decompensation when taking Lamotrigine. It is created by eHealthMe based on reports of 72,834 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Neurological decompensation?

Neurological decompensation (inability of brain to maintain proper function) is found to be associated with 264 drugs and 451 conditions by eHealthMe. Check the latest studies of Neurological decompensation.

On Jul, 15, 2026

72,834 people reported to have side effects when taking Lamotrigine.
Among them, 46 people (0.06%) have Neurological decompensation.

Could Lamotrigine cause Neurological decompensation?

Among these 46 people:

How long have people been on Lamotrigine when they have Neurological decompensation? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Neurological decompensation when taking Lamotrigine? *

  • female: 13.95 %
  • male: 86.05 %

What is the age of people who have Neurological decompensation when taking Lamotrigine? *

  • 0-1: 0.0 %
  • 2-9: 32.35 %
  • 10-19: 2.94 %
  • 20-29: 38.24 %
  • 30-39: 14.71 %
  • 40-49: 2.94 %
  • 50-59: 0.0 %
  • 60+: 8.82 %

What are other drugs people take besides Lamotrigine? *

  1. Levetiracetam: 29 people, 63.04%
  2. Diazepam: 16 people, 34.78%
  3. Perampanel: 13 people, 28.26%
  4. Carbamazepine: 10 people, 21.74%
  5. Lacosamide: 10 people, 21.74%
  6. Phenytoin: 2 people, 4.35%
  7. Anafranil: 2 people, 4.35%
  8. Vimpat: 2 people, 4.35%
  9. Clonazepam: 1 person, 2.17%
  10. Clobazam: 1 person, 2.17%

What are other side effects people have besides Neurological decompensation? *

  1. Encephalopathy (functioning of the brain is affected by some agent or condition): 22 people, 47.83%
  2. Hyperpyrexia (extremely high fever): 19 people, 41.30%
  3. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 19 people, 41.30%
  4. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 19 people, 41.30%
  5. Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 19 people, 41.30%
  6. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 18 people, 39.13%
  7. Acute Hepatic Failure: 17 people, 36.96%
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 16 people, 34.78%
  9. Movement - Uncontrolled Or Slow: 16 people, 34.78%
  10. Developmental Delay: 15 people, 32.61%

What are the existing conditions these people have? *

  1. Depression: 2 people, 4.35%
  2. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 4.35%
  3. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 1 person, 2.17%
  4. Psoriasis (immune-mediated disease that affects the skin): 1 person, 2.17%
  5. Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 1 person, 2.17%
  6. Poisoning Deliberate: 1 person, 2.17%
  7. Pneumonia Mycoplasmal (mycoplasma pneumonia (mp) is a contagious respiratory infection): 1 person, 2.17%
  8. Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 1 person, 2.17%
  9. Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 2.17%
  10. Oral Candidiasis (fungal infection of mouth): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Lamotrigine and have Neurological decompensation?

- Check whether Neurological decompensation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamotrigine:

Neurological decompensation treatments and more:

How severe was Neurological decompensation and when was it recovered:

Expand to all the drugs that have ingredients of lamotrigine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neurological decompensation:

Browse all the conditions that are associated with Neurological decompensation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamotrigine) and Lamotrigine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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