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Lansoprazole and Subcutaneous emphysema - a phase IV clinical study of FDA data

Summary:

Subcutaneous emphysema is reported as a side effect among people who take Lansoprazole (lansoprazole), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Renagel, and have Hyperphosphataemia.

The phase IV clinical study analyzes which people have Subcutaneous emphysema when taking Lansoprazole. It is created by eHealthMe based on reports of 128,069 people who have side effects when taking Lansoprazole from the FDA, and is updated regularly.

What is Lansoprazole?

Lansoprazole has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 129,666 Lansoprazole users. Check the latest studies of Lansoprazole.

What is Subcutaneous emphysema?

Subcutaneous emphysema (smooth bulging of the skin) is found to be associated with 169 drugs and 526 conditions by eHealthMe. Check the latest studies of Subcutaneous emphysema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

128,069 people reported to have side effects when taking Lansoprazole.
Among them, 16 people (0.01%) have Subcutaneous emphysema.

Could Lansoprazole cause Subcutaneous emphysema?

Among these 16 people:

How long have people been on Lansoprazole when they have Subcutaneous emphysema? *

  • < 1 month: 80 %
  • 1 - 6 months: 20 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Subcutaneous emphysema when taking Lansoprazole? *

  • female: 43.75 %
  • male: 56.25 %

What is the age of people who have Subcutaneous emphysema when taking Lansoprazole? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 18.75 %
  • 60+: 81.25 %

What are other drugs people take besides Lansoprazole? *

  1. Losartan Potassium And Hydrochlorothiazide: 4 people, 25.00%
  2. Allopurinol: 4 people, 25.00%
  3. Lasix: 4 people, 25.00%
  4. Renagel: 4 people, 25.00%
  5. Colace: 3 people, 18.75%
  6. Prednisolone: 3 people, 18.75%
  7. Prednisone: 3 people, 18.75%
  8. Rabeprazole: 3 people, 18.75%
  9. Asa: 3 people, 18.75%
  10. Methotrexate: 2 people, 12.50%

What are other side effects people have besides Subcutaneous emphysema? *

  1. Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 6 people, 37.50%
  2. Multi-Organ Failure (multisystem organ failure): 6 people, 37.50%
  3. Pneumomediastinum (air is present in the mediastinum): 5 people, 31.25%
  4. Large Intestine Perforation (hole in large intestine): 4 people, 25.00%
  5. Pleural Effusion (water on the lungs): 3 people, 18.75%
  6. Lung Adenocarcinoma (a form of non-small cell lung cancer): 3 people, 18.75%
  7. Pneumonia: 3 people, 18.75%
  8. Thrombocytopenia (decrease of platelets in blood): 3 people, 18.75%
  9. Cryptogenic Organizing Pneumonia (small airways (bronchioles) and air exchange sac (alveoli) become inflamed with connective tissue): 2 people, 12.50%
  10. Dyspnea (difficult or laboured breathing): 2 people, 12.50%

What are the existing conditions these people have? *

  1. Constipation: 4 people, 25.00%
  2. Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 4 people, 25.00%
  3. Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood): 4 people, 25.00%
  4. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 18.75%
  5. Procedural Pain: 3 people, 18.75%
  6. Indigestion: 3 people, 18.75%
  7. Tumor Lysis Syndrome: 2 people, 12.50%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
  9. Hypokalemia (low potassium): 2 people, 12.50%
  10. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Lansoprazole and have Subcutaneous emphysema?

- Check whether Subcutaneous emphysema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lansoprazole:

Subcutaneous emphysema treatments and more:

How severe was Subcutaneous emphysema and when was it recovered:

Expand to all the drugs that have ingredients of lansoprazole:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lansoprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Subcutaneous emphysema:

Browse all the conditions that are associated with Subcutaneous emphysema:

How the study uses the data?

The study uses data from the FDA. It is based on lansoprazole (the active ingredients of Lansoprazole) and Lansoprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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