Legalon and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Legalon (milk thistle), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Aloxi, and have High blood pressure.

The phase IV clinical study analyzes which people have Constipation when taking Legalon. It is created by eHealthMe based on reports of 441 people who have side effects when taking Legalon from the FDA, and is updated regularly.

What is Legalon?

Legalon has active ingredients of milk thistle. eHealthMe is studying from 456 Legalon users. Check the latest studies of Legalon.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,614 conditions by eHealthMe. Check the latest studies of Constipation.

On Jul, 26, 2026

441 people reported to have side effects when taking Legalon.
Among them, 16 people (3.63%) have Constipation.

Among these 16 people:

How long have people been on Legalon when they have Constipation? *

What is the gender of people who have Constipation when taking Legalon? *

female: 18.75 %
male: 81.25 %

What is the age of people who have Constipation when taking Legalon? *

What are other drugs people take besides Legalon? *

What are other side effects people have besides Constipation? *

Indigestion: 8 people, 50.00%
Gastric Ulcer (stomach ulcer): 6 people, 37.50%
Nausea (feeling of having an urge to vomit): 5 people, 31.25%
Oesophageal Varices Haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus): 5 people, 31.25%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 5 people, 31.25%
Hair Loss: 4 people, 25.00%
High Blood Pressure: 4 people, 25.00%
Hoarseness Or Changing Voice: 4 people, 25.00%
Diarrhea: 4 people, 25.00%
Infusion Related Reaction: 4 people, 25.00%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 43.75%
Diabetes: 6 people, 37.50%
Hepatitis B: 5 people, 31.25%
Gastritis (inflammation of stomach): 5 people, 31.25%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 25.00%
Hyperammonaemia: 4 people, 25.00%
Productive Cough: 4 people, 25.00%
Hepatic Neoplasm Malignant (liver cancer): 4 people, 25.00%
Fever: 2 people, 12.50%
Back Pain: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Legalon and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Legalon:

Legalon (456 reports)

Constipation treatments and more:

Constipation (337,879 reports)

Browse all side effects of Legalon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,614 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milk thistle (the active ingredients of Legalon) and Legalon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.