Letairis and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Letairis (ambrisentan), especially for people who are female, 50-59 old, also take Klonopin, and have Pain.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Letairis. It is created by eHealthMe based on reports of 93,991 people who have side effects when taking Letairis from the FDA, and is updated regularly.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,347 drugs and 1,692 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Jul, 10, 2026

93,991 people reported to have side effects when taking Letairis.
Among them, 14 people (0.01%) have Aseptic necrosis.

Among these 14 people:

What is the gender of people who have Aseptic necrosis when taking Letairis? *

female: 92.86 %
male: 7.14 %

What is the age of people who have Aseptic necrosis when taking Letairis? *

What are other drugs people take besides Letairis? *

What are other side effects people have besides Aseptic necrosis? *

Disease Progression: 8 people, 57.14%
Dyspnea (difficult or laboured breathing): 3 people, 21.43%
Fatigue (feeling of tiredness): 3 people, 21.43%
Toothaches (tooth pain): 1 person, 7.14%
Tooth Fracture: 1 person, 7.14%
Aphthous Stomatitis (mouth ulcer): 1 person, 7.14%
Back Pain: 1 person, 7.14%
Dental Caries: 1 person, 7.14%
Diarrhea: 1 person, 7.14%
Fever: 1 person, 7.14%

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 8 people, 57.14%
Pain: 8 people, 57.14%
Anaemia (lack of blood): 7 people, 50.00%
Osteoporosis (bones weak and more likely to break): 1 person, 7.14%
Liver Disorder (liver diseases): 1 person, 7.14%
Glioma (a type of tumour that starts in the brain or spine): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Letairis and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Letairis:

Letairis (94,041 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Letairis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,347 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,692 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ambrisentan (the active ingredients of Letairis) and Letairis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.