Levothyroxine sodium and Extremity contracture - a phase IV clinical study of FDA data

Summary:

Extremity contracture is reported as a side effect among people who take Levothyroxine sodium (levothyroxine sodium), especially for people who are female, 20-29 old, have been taking the drug for 5 - 10 years also take Magnevist, and have High blood pressure.

The phase IV clinical study analyzes which people have Extremity contracture when taking Levothyroxine sodium. It is created by eHealthMe based on reports of 122,907 people who have side effects when taking Levothyroxine sodium from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,812 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Extremity contracture?

Extremity contracture (permanent shortening of a muscle or joint of arms and legs) is found to be associated with 208 drugs and 258 conditions by eHealthMe. Check the latest studies of Extremity contracture.

On Jul, 12, 2026

122,907 people reported to have side effects when taking Levothyroxine sodium.
Among them, 34 people (0.03%) have Extremity contracture.

Could Levothyroxine sodium cause Extremity contracture?

Among these 34 people:

How long have people been on Levothyroxine sodium when they have Extremity contracture? *

What is the gender of people who have Extremity contracture when taking Levothyroxine sodium? *

female: 56.25 %
male: 43.75 %

What is the age of people who have Extremity contracture when taking Levothyroxine sodium? *

What are other drugs people take besides Levothyroxine sodium? *

What are other side effects people have besides Extremity contracture? *

Nephrogenic Systemic Fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease): 23 people, 67.65%
Pain: 19 people, 55.88%
Skin Hyperpigmentation (disorders affect the colour of your skin): 14 people, 41.18%
Stress And Anxiety: 12 people, 35.29%
Skin Hypertrophy (skin cells enlarges): 12 people, 35.29%
Mobility Decreased (ability to move is reduced): 11 people, 32.35%
Skin Induration (an abnormally hard spot or area on the skin): 11 people, 32.35%
Common Peroneal Nerve Dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes): 11 people, 32.35%
Dry Skin: 10 people, 29.41%
Skin Disorder (skin disease): 10 people, 29.41%

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 38.24%
Nuclear Magnetic Resonance Imaging Brain: 9 people, 26.47%
Nuclear Magnetic Resonance Imaging Abdominal: 9 people, 26.47%
Pain: 5 people, 14.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 11.76%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 11.76%
Diabetes: 4 people, 11.76%
Tumor: 2 people, 5.88%
Depression: 2 people, 5.88%
Adrenal Disorder: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Levothyroxine sodium and have Extremity contracture?

- Check whether Extremity contracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothyroxine sodium:

Levothyroxine sodium (129,812 reports)

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extremity contracture:

Extremity contracture (208 drugs)

Browse all the conditions that are associated with Extremity contracture:

Extremity contracture (258 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothyroxine sodium) and Levothyroxine sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.