Librium and Flat affect - a phase IV clinical study of FDA data

Summary:

Flat affect is reported as a side effect among people who take Librium (chlordiazepoxide hydrochloride), especially for people who are male, 60+ old, also take Duopa, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Flat affect when taking Librium. It is created by eHealthMe based on reports of 2,250 people who have side effects when taking Librium from the FDA, and is updated regularly.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

What is Flat affect?

Flat affect (absence of emotional response to a situation) is found to be associated with 304 drugs and 454 conditions by eHealthMe. Check the latest studies of Flat affect.

On Jan, 07, 2026

2,250 people reported to have side effects when taking Librium.
Among them, 12 people (0.53%) have Flat affect.

Among these 12 people:

What is the gender of people who have Flat affect when taking Librium? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Flat affect when taking Librium? *

What are other drugs people take besides Librium? *

What are other side effects people have besides Flat affect? *

Weight Decreased: 8 people, 66.67%
Fall: 8 people, 66.67%
Hallucinations (sensations that appear real but are created by your mind): 7 people, 58.33%
Abnormal Behavior: 5 people, 41.67%
Aggression: 5 people, 41.67%
Agitation (state of anxiety or nervous excitement): 5 people, 41.67%
Ventricular Extrasystoles (premature cardiac contraction): 5 people, 41.67%
Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 41.67%
Delirium (wild excitement): 5 people, 41.67%
Loss Of Consciousness: 5 people, 41.67%

What are the existing conditions these people have? *

Parkinson's Disease: 6 people, 50.00%
Ulcer Haemorrhage (bleeding ulcer): 5 people, 41.67%
Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 41.67%
Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 41.67%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 33.33%
Constipation: 2 people, 16.67%
Multiple Myeloma (cancer of the plasma cells): 1 person, 8.33%
Depression: 1 person, 8.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Librium and have Flat affect?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Librium:

Librium (2,490 reports)

Flat affect treatments and more:

Flat affect (2,784 reports)

How severe was Flat affect and when was it recovered:

Flat affect in Librium

Expand to all the drugs that have ingredients of chlordiazepoxide hydrochloride:

Flat affect and drugs with ingredients of chlordiazepoxide hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Librium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flat affect:

Flat affect (304 drugs)

Browse all the conditions that are associated with Flat affect:

Flat affect (454 conditions)

Drugs similar to Librium and Flat affect :

How the study uses the data?

The study uses data from the FDA. It is based on chlordiazepoxide hydrochloride (the active ingredients of Librium) and Librium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.