Seroquel and Flat affect - a phase IV clinical study of FDA data

Summary:

Flat affect is reported as a side effect among people who take Seroquel (quetiapine fumarate), especially for people who are male, 40-49 old, have been taking the drug for 5 - 10 years also take Zyprexa, and have Sleep disorder.

The phase IV clinical study analyzes which people have Flat affect when taking Seroquel. It is created by eHealthMe based on reports of 113,615 people who have side effects when taking Seroquel from the FDA, and is updated regularly.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,276 Seroquel users. Check the latest studies of Seroquel.

What is Flat affect?

Flat affect (absence of emotional response to a situation) is found to be associated with 310 drugs and 453 conditions by eHealthMe. Check the latest studies of Flat affect.

On Sep, 09, 2025

113,615 people reported to have side effects when taking Seroquel.
Among them, 77 people (0.07%) have Flat affect.

Among these 77 people:

How long have people been on Seroquel when they have Flat affect? *

What is the gender of people who have Flat affect when taking Seroquel? *

female: 36.11 %
male: 63.89 %

What is the age of people who have Flat affect when taking Seroquel? *

What are other drugs people take besides Seroquel? *

What are other side effects people have besides Flat affect? *

Fatigue (feeling of tiredness): 30 people, 38.96%
Agitation (state of anxiety or nervous excitement): 21 people, 27.27%
Drowsiness: 18 people, 23.38%
Headache (pain in head): 16 people, 20.78%
Confusional State: 16 people, 20.78%
Drug Ineffective: 16 people, 20.78%
Feeling Abnormal: 15 people, 19.48%
Mood Swings (an extreme or rapid change in mood): 14 people, 18.18%
Memory Loss: 14 people, 18.18%
Irritability: 14 people, 18.18%

What are the existing conditions these people have? *

Sleep Disorder: 12 people, 15.58%
Psychotic Disorder: 11 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 7 people, 9.09%
Obsessive Thoughts (intrusive thoughts that produce uneasiness, apprehension, fear, or worry): 7 people, 9.09%
Stress And Anxiety: 7 people, 9.09%
Borderline Personality Disorder: 7 people, 9.09%
Agitation (state of anxiety or nervous excitement): 6 people, 7.79%
Loss Of Libido (loss of sexual urge): 5 people, 6.49%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 5.19%
Constipation: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

Do you take Seroquel and have Flat affect?

- Check whether Flat affect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Seroquel:

Seroquel (120,276 reports)

Flat affect treatments and more:

Flat affect (2,784 reports)

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flat affect:

Flat affect (310 drugs)

Browse all the conditions that are associated with Flat affect:

Flat affect (453 conditions)

Drugs similar to Seroquel and Flat affect :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on quetiapine fumarate (the active ingredients of Seroquel) and Seroquel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.