Lidocaine and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Lidocaine (lidocaine), especially for people who are female, 30-39 old, have been taking the drug for 1 - 2 years also take Propofol, and have Anaesthesia.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Lidocaine. It is created by eHealthMe based on reports of 27,239 people who have side effects when taking Lidocaine from the FDA, and is updated regularly.

What is Lidocaine?

Lidocaine has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 27,555 Lidocaine users. Check the latest studies of Lidocaine.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 780 drugs and 1,036 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

27,239 people reported to have side effects when taking Lidocaine.
Among them, 30 people (0.11%) have Muscle rigidity.

Among these 30 people:

How long have people been on Lidocaine when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Lidocaine? *

female: 60 %
male: 40 %

What is the age of people who have Muscle rigidity when taking Lidocaine? *

What are other drugs people take besides Lidocaine? *

What are other side effects people have besides Muscle rigidity? *

Arrhythmias (irregular heartbeat): 7 people, 23.33%
Agitation (state of anxiety or nervous excitement): 5 people, 16.67%
Fever: 5 people, 16.67%
Loss Of Consciousness: 4 people, 13.33%
Hypotension (abnormally low blood pressure): 3 people, 10.00%
Parkinson's Disease: 3 people, 10.00%
Hyperthermia Malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions): 3 people, 10.00%
Feeling Abnormal: 3 people, 10.00%
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 3 people, 10.00%
High Blood Pressure: 3 people, 10.00%

What are the existing conditions these people have? *

Anaesthesia: 6 people, 20.00%
Perioperative Analgesia: 2 people, 6.67%
Sedation: 1 person, 3.33%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 3.33%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 3.33%
Parkinson's Disease: 1 person, 3.33%
Neuromuscular Blockade: 1 person, 3.33%
High Blood Pressure: 1 person, 3.33%
General Anaesthesia: 1 person, 3.33%
Fever: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lidocaine and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lidocaine:

Lidocaine (27,555 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Lidocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (780 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,036 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lidocaine (the active ingredients of Lidocaine) and Lidocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.