Lisinopril and hydrochlorothiazide and Apathy - a phase IV clinical study of FDA data

Summary:

Apathy is reported as a side effect among people who take Lisinopril and hydrochlorothiazide (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, also take Acetylsalicylic Acid, and have Depression.

The phase IV clinical study analyzes which people have Apathy when taking Lisinopril and hydrochlorothiazide. It is created by eHealthMe based on reports of 8,870 people who have side effects when taking Lisinopril and hydrochlorothiazide from the FDA, and is updated regularly.

What is Lisinopril and hydrochlorothiazide?

Lisinopril and hydrochlorothiazide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 10,259 Lisinopril and hydrochlorothiazide users. Check the latest studies of Lisinopril and hydrochlorothiazide.

What is Apathy?

Apathy is found to be associated with 800 drugs and 1,162 conditions by eHealthMe. Check the latest studies of Apathy.

On Jul, 14, 2026

8,870 people reported to have side effects when taking Lisinopril and hydrochlorothiazide.
Among them, 11 people (0.12%) have Apathy.

Could Lisinopril and hydrochlorothiazide cause Apathy?

Among these 11 people:

What is the gender of people who have Apathy when taking Lisinopril and hydrochlorothiazide? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Apathy when taking Lisinopril and hydrochlorothiazide? *

What are other drugs people take besides Lisinopril and hydrochlorothiazide? *

Chantix: 4 people, 36.36%
Ranitidine: 4 people, 36.36%
Tylenol: 4 people, 36.36%
Cymbalta: 4 people, 36.36%
Metformin Hydrochloride: 4 people, 36.36%
Glimepiride: 4 people, 36.36%
Acetylsalicylic Acid: 4 people, 36.36%
Acetaminophen: 3 people, 27.27%
Baclofen: 2 people, 18.18%
Actos: 2 people, 18.18%

What are other side effects people have besides Apathy? *

Weight Decreased: 5 people, 45.45%
Weakness: 5 people, 45.45%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 45.45%
Drowsiness: 5 people, 45.45%
Depression: 5 people, 45.45%
Fatigue (feeling of tiredness): 5 people, 45.45%
Diabetes: 4 people, 36.36%
Vision Blurred: 4 people, 36.36%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 36.36%
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem): 4 people, 36.36%

What are the existing conditions these people have? *

Depression: 5 people, 45.45%
Quit Smoking: 4 people, 36.36%
Diabetes: 2 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 18.18%
Gastric Disorder (disease of stomach): 2 people, 18.18%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%
Joint Pain: 1 person, 9.09%
Polypoidal Choroidal Vasculopathy (polyp-like sub-retinal pigment epithelium vascular abnormalities predominantly found in the macula and peripapillary region): 1 person, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Lisinopril and hydrochlorothiazide and have Apathy?

- Check whether Apathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lisinopril and hydrochlorothiazide:

Lisinopril and hydrochlorothiazide (10,259 reports)

Apathy treatments and more:

Apathy (16,905 reports)

How severe was Apathy and when was it recovered:

Apathy in Lisinopril and hydrochlorothiazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Apathy and drugs with ingredients of hydrochlorothiazide; lisinopril

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lisinopril and hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Apathy:

Apathy (800 drugs)

Browse all the conditions that are associated with Apathy:

Apathy (1,162 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Lisinopril and hydrochlorothiazide) and Lisinopril and hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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