Lupron and Bone erosion - a phase IV clinical study of FDA data

Summary:

Bone erosion is reported as a side effect among people who take Lupron (leuprolide acetate), especially for people who are male, 60+ old, also take Zometa, and have Constipation.

The phase IV clinical study analyzes which people have Bone erosion when taking Lupron. It is created by eHealthMe based on reports of 41,483 people who have side effects when taking Lupron from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Bone erosion?

Bone erosion is found to be associated with 495 drugs and 297 conditions by eHealthMe. Check the latest studies of Bone erosion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

41,483 people reported to have side effects when taking Lupron.
Among them, 40 people (0.1%) have Bone erosion.

Among these 40 people:

What is the gender of people who have Bone erosion when taking Lupron? *

female: 5 %
male: 95 %

What is the age of people who have Bone erosion when taking Lupron? *

What are other drugs people take besides Lupron? *

What are other side effects people have besides Bone erosion? *

Pain: 37 people, 92.50%
Stress And Anxiety: 36 people, 90.00%
Metastases To Bone (cancer spreads to bone): 33 people, 82.50%
Pain In Jaw: 33 people, 82.50%
Osteonecrosis Of Jaw (death of bone of jaw): 29 people, 72.50%
Bone Disorder: 28 people, 70.00%
Constipation: 28 people, 70.00%
Anaemia (lack of blood): 27 people, 67.50%
Urinary Tract Infection: 25 people, 62.50%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 25 people, 62.50%

What are the existing conditions these people have? *

Constipation: 7 people, 17.50%
Bone Density Decreased: 5 people, 12.50%
Bone Loss: 2 people, 5.00%
Suicide Attempt: 1 person, 2.50%
Procedural Vomiting: 1 person, 2.50%
Osteoporosis (bones weak and more likely to break): 1 person, 2.50%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 2.50%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 1 person, 2.50%
High Blood Pressure: 1 person, 2.50%
High Blood Cholesterol: 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and have Bone erosion?

- Check whether Bone erosion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lupron:

Lupron (42,122 reports)

Bone erosion treatments and more:

Bone erosion (4,590 reports)

Browse all side effects of Lupron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone erosion:

Bone erosion (495 drugs)

Browse all the conditions that are associated with Bone erosion:

Bone erosion (297 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.