Lupron and Ddd - a phase IV clinical study of FDA data

Summary:

Ddd is reported as a side effect among people who take Lupron (leuprolide acetate), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Ddd when taking Lupron. It is created by eHealthMe based on reports of 41,483 people who have side effects when taking Lupron from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,120 Lupron users. Check the latest studies of Lupron.

What is Ddd?

Ddd is found to be associated with 1,408 drugs and 1,391 conditions by eHealthMe. Check the latest studies of Ddd.

On Oct, 14, 2025

41,483 people reported to have side effects when taking Lupron.
Among them, 218 people (0.53%) have Ddd.

Among these 218 people:

How long have people been on Lupron when they have Ddd? *

What is the gender of people who have Ddd when taking Lupron? *

female: 36.32 %
male: 63.68 %

What is the age of people who have Ddd when taking Lupron? *

What are other drugs people take besides Lupron? *

What are other side effects people have besides Ddd? *

Pain: 161 people, 73.85%
Osteonecrosis Of Jaw (death of bone of jaw): 150 people, 68.81%
Stress And Anxiety: 144 people, 66.06%
Back Pain: 119 people, 54.59%
Anaemia (lack of blood): 108 people, 49.54%
Joint Pain: 104 people, 47.71%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 103 people, 47.25%
Injury: 102 people, 46.79%
Depression: 102 people, 46.79%
Fatigue (feeling of tiredness): 94 people, 43.12%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 44 people, 20.18%
Depression: 27 people, 12.39%
High Blood Pressure: 20 people, 9.17%
Multiple Myeloma (cancer of the plasma cells): 19 people, 8.72%
Pain: 17 people, 7.80%
Osteoporosis (bones weak and more likely to break): 16 people, 7.34%
Stress And Anxiety: 15 people, 6.88%
Bone Density Abnormal: 15 people, 6.88%
Neoplasm Malignant (cancer tumour): 14 people, 6.42%
Gynecomastia (enlargement of the gland tissue of the male breast): 13 people, 5.96%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and have Ddd?

- Check whether Ddd is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lupron:

Lupron (42,120 reports)

Ddd treatments and more:

Ddd (19,905 reports)

Common Lupron side effects:

Browse all side effects of Lupron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ddd:

Fosamax side effect: Ddd (3,047 reports)
Zometa side effect: Ddd (2,149 reports)
Prednisone side effect: Ddd (1,905 reports)
Aspirin side effect: Ddd (1,558 reports)
Humira side effect: Ddd (1,378 reports)
Aredia side effect: Ddd (1,331 reports)
Gabapentin side effect: Ddd (1,258 reports)
Methotrexate side effect: Ddd (1,183 reports)
Vioxx side effect: Ddd (1,076 reports)
Celebrex side effect: Ddd (1,050 reports)

Browse all the drugs that are associated with Ddd:

Ddd (1,408 drugs)

Common conditions associated with Ddd:

Osteoporosis: 2,599 reports
Thin bones: 2,465 reports
Ra: 1,738 reports
Osteopenia: 1,259 reports
Pain exacerbated: 1,225 reports
Alternative medicine - pain relief: 1,223 reports
Hbp: 1,031 reports
Multiple sclerosis: 1,020 reports
Acupuncture and pain: 831 reports
Antidepressant therapy: 681 reports

Browse all the conditions that are associated with Ddd:

Ddd (1,391 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.