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Lupron and Icterus - a phase IV clinical study of FDA data

Summary:

Icterus is reported as a side effect among people who take Lupron (leuprolide acetate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have Cardiac disorder.

The phase IV clinical study analyzes which people have Icterus when taking Lupron. It is created by eHealthMe based on reports of 41,483 people who have side effects when taking Lupron from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Icterus?

Icterus (yellowish pigmentation of the skin) is found to be associated with 2,006 drugs and 3,028 conditions by eHealthMe. Check the latest studies of Icterus.

On Apr, 06, 2026

41,483 people reported to have side effects when taking Lupron.
Among them, 34 people (0.08%) have Icterus.

Could Lupron cause Icterus?

Among these 34 people:

How long have people been on Lupron when they have Icterus? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 25 %
  • 10+ years: 0.0 %

What is the gender of people who have Icterus when taking Lupron? *

  • female: 35.48 %
  • male: 64.52 %

What is the age of people who have Icterus when taking Lupron? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 4.35 %
  • 30-39: 4.35 %
  • 40-49: 26.09 %
  • 50-59: 0.0 %
  • 60+: 65.22 %

What are other drugs people take besides Lupron? *

  1. Amlodipine: 8 people, 23.53%
  2. Tylenol: 4 people, 11.76%
  3. Casodex: 4 people, 11.76%
  4. Acetylsalicylic Acid: 3 people, 8.82%
  5. Zometa: 3 people, 8.82%
  6. Ketoconazole: 3 people, 8.82%
  7. Motrin: 3 people, 8.82%
  8. Neurontin: 3 people, 8.82%
  9. Oxycodone: 3 people, 8.82%
  10. Palbociclib: 3 people, 8.82%

What are other side effects people have besides Icterus? *

  1. Blood Bilirubin Increased: 11 people, 32.35%
  2. Thrombocytopenia (decrease of platelets in blood): 10 people, 29.41%
  3. Alanine Aminotransferase Increased: 9 people, 26.47%
  4. Scleral Discoloration: 8 people, 23.53%
  5. Faeces Pale: 7 people, 20.59%
  6. Eye Color Change: 7 people, 20.59%
  7. Abdominal Discomfort: 7 people, 20.59%
  8. Weakness: 5 people, 14.71%
  9. Pain: 4 people, 11.76%
  10. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 4 people, 11.76%

What are the existing conditions these people have? *

  1. Renal Cell Carcinoma (a kidney cancer): 8 people, 23.53%
  2. Cardiac Disorder: 8 people, 23.53%
  3. Breast Cancer: 3 people, 8.82%
  4. Discomfort: 3 people, 8.82%
  5. Pain: 3 people, 8.82%
  6. Metastases To Bone (cancer spreads to bone): 3 people, 8.82%
  7. Stress And Anxiety: 3 people, 8.82%
  8. Fever: 3 people, 8.82%
  9. Prostate Cancer Metastatic: 2 people, 5.88%
  10. Diabetes: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and have Icterus?

- Check whether Icterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lupron:

Icterus treatments and more:

How severe was Icterus and when was it recovered:

Expand to all the drugs that have ingredients of leuprolide acetate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lupron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Icterus:

Browse all the conditions that are associated with Icterus:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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