Megace and Mastication disorder - a phase IV clinical study of FDA data

Summary:

Mastication disorder is reported as a side effect among people who take Megace (megestrol acetate), especially for people who are female, 60+ old, also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Mastication disorder when taking Megace. It is created by eHealthMe based on reports of 9,969 people who have side effects when taking Megace from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Mastication disorder?

Mastication disorder (disease of chewing food) is found to be associated with 710 drugs and 548 conditions by eHealthMe. Check the latest studies of Mastication disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

9,969 people reported to have side effects when taking Megace.
Among them, 50 people (0.5%) have Mastication disorder.

Could Megace cause Mastication disorder?

Among these 50 people:

What is the gender of people who have Mastication disorder when taking Megace? *

female: 70 %
male: 30 %

What is the age of people who have Mastication disorder when taking Megace? *

What are other drugs people take besides Megace? *

What are other side effects people have besides Mastication disorder? *

Pain: 47 people, 94.00%
Stress And Anxiety: 47 people, 94.00%
Impaired Healing: 46 people, 92.00%
Bone Disorder: 44 people, 88.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 43 people, 86.00%
Dyspnea (difficult or laboured breathing): 42 people, 84.00%
Back Pain: 41 people, 82.00%
Spinal Osteoarthritis (joint cartilage loss in spine): 41 people, 82.00%
Weight Decreased: 37 people, 74.00%
Osteonecrosis Of Jaw (death of bone of jaw): 37 people, 74.00%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 25 people, 50.00%
Multiple Myeloma (cancer of the plasma cells): 12 people, 24.00%
Toothaches (tooth pain): 11 people, 22.00%
Muscle Spasms (muscle contraction): 11 people, 22.00%
Depression: 4 people, 8.00%
High Blood Pressure: 4 people, 8.00%
Bone Neoplasm Malignant (cancer of bone): 3 people, 6.00%
Cardiac Failure: 3 people, 6.00%
Prostate Cancer Metastatic: 2 people, 4.00%
Breast Cancer: 2 people, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Megace and have Mastication disorder?

- Check whether Mastication disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Megace:

Megace (10,095 reports)

Browse all side effects of Megace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mastication disorder:

Mastication disorder (710 drugs)

Browse all the conditions that are associated with Mastication disorder:

Mastication disorder (548 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on megestrol acetate (the active ingredients of Megace) and Megace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.