Memantine hydrochloride and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Memantine hydrochloride (memantine hydrochloride), especially for people who are male, 60+ old, also take Metoprolol Succinate, and have Diarrhea.

The phase IV clinical study analyzes which people have Mental status changes when taking Memantine hydrochloride. It is created by eHealthMe based on reports of 3,046 people who have side effects when taking Memantine hydrochloride from the FDA, and is updated regularly.

What is Memantine hydrochloride?

Memantine hydrochloride has active ingredients of memantine hydrochloride. eHealthMe is studying from 3,076 Memantine hydrochloride users. Check the latest studies of Memantine hydrochloride.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,493 drugs and 1,760 conditions by eHealthMe. Check the latest studies of Mental status changes.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

3,046 people reported to have side effects when taking Memantine hydrochloride.
Among them, 32 people (1.05%) have Mental status changes.

Could Memantine hydrochloride cause Mental status changes?

Among these 32 people:

What is the gender of people who have Mental status changes when taking Memantine hydrochloride? *

female: 40 %
male: 60 %

What is the age of people who have Mental status changes when taking Memantine hydrochloride? *

What are other drugs people take besides Memantine hydrochloride? *

What are other side effects people have besides Mental status changes? *

Agitation (state of anxiety or nervous excitement): 9 people, 28.12%
Confusional State: 9 people, 28.12%
Fatigue (feeling of tiredness): 8 people, 25.00%
Hypertensive Crisis: 6 people, 18.75%
Fall: 6 people, 18.75%
Echolalia (meaningless repetition of another person's spoken words -psychiatric disorder): 6 people, 18.75%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 6 people, 18.75%
Insomnia (sleeplessness): 5 people, 15.62%
Delirium (wild excitement): 5 people, 15.62%
Weight Decreased: 5 people, 15.62%

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 12.50%
Pain: 4 people, 12.50%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 4 people, 12.50%
Fever: 4 people, 12.50%
Diarrhea: 4 people, 12.50%
Headache (pain in head): 3 people, 9.38%
Dizziness: 2 people, 6.25%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 6.25%
Oedema (fluid collection in tissue): 1 person, 3.12%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Memantine hydrochloride and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Memantine hydrochloride:

Memantine hydrochloride (3,076 reports)

Browse all side effects of Memantine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,493 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on memantine hydrochloride (the active ingredients of Memantine hydrochloride) and Memantine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.