Methotrexate and Nail bed infection - a phase IV clinical study of FDA data

Summary:

Nail bed infection is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 40-49 old, also take Folic Acid, and have Anaemia.

The phase IV clinical study analyzes which people have Nail bed infection when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

What is Nail bed infection?

Nail bed infection is found to be associated with 28 drugs and 189 conditions by eHealthMe. Check the latest studies of Nail bed infection.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 15 people (0.0%) have Nail bed infection.

Could Methotrexate cause Nail bed infection?

Among these 15 people:

What is the gender of people who have Nail bed infection when taking Methotrexate? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Nail bed infection when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Nail bed infection? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 33.33%
Joint Pain: 5 people, 33.33%
Depression: 5 people, 33.33%
Gastroenteritis Viral (inflammation of stomach and intestine caused by virus infection): 4 people, 26.67%
Sinusitis (inflammation of sinus): 4 people, 26.67%
Eye Infection: 4 people, 26.67%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 26.67%
Fatigue (feeling of tiredness): 4 people, 26.67%
Respiratory Tract Infection: 4 people, 26.67%
Hair Loss: 4 people, 26.67%

What are the existing conditions these people have? *

Indigestion: 3 people, 20.00%
Anaemia (lack of blood): 3 people, 20.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 6.67%
Lymphoedema (localized fluid retention and tissue swelling): 1 person, 6.67%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 6.67%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 6.67%
Diarrhea: 1 person, 6.67%
Central Nervous System Lymphoma (cancer of central nervous system forms in lymph tissue): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Nail bed infection?

- Check whether Nail bed infection is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,314 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nail bed infection:

Nail bed infection (28 drugs)

Browse all the conditions that are associated with Nail bed infection:

Nail bed infection (189 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.