Mercaptopurine and Peripheral neuropathy - a phase IV clinical study of FDA data

Summary:

Peripheral neuropathy is reported as a side effect among people who take Mercaptopurine (mercaptopurine), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Methotrexate, and have Acute lymphocytic leukemia (all).

The phase IV clinical study analyzes which people have Peripheral neuropathy when taking Mercaptopurine. It is created by eHealthMe based on reports of 22,744 people who have side effects when taking Mercaptopurine from the FDA, and is updated regularly.

What is Mercaptopurine?

Mercaptopurine has active ingredients of mercaptopurine. It is often used in crohn's disease. eHealthMe is studying from 23,013 Mercaptopurine users. Check the latest studies of Mercaptopurine.

What is Peripheral neuropathy?

Peripheral neuropathy (damage to nerves of the peripheral nervous system) is found to be associated with 504 drugs and 879 conditions by eHealthMe. Check the latest studies of Peripheral neuropathy.

On Jul, 09, 2026

22,744 people reported to have side effects when taking Mercaptopurine.
Among them, 12 people (0.05%) have Peripheral neuropathy.

Could Mercaptopurine cause Peripheral neuropathy?

Among these 12 people:

How long have people been on Mercaptopurine when they have Peripheral neuropathy? *

What is the gender of people who have Peripheral neuropathy when taking Mercaptopurine? *

female: 16.67 %
male: 83.33 %

What is the age of people who have Peripheral neuropathy when taking Mercaptopurine? *

What are other drugs people take besides Mercaptopurine? *

What are other side effects people have besides Peripheral neuropathy? *

Hyporeflexia (a condition of below normal or absent reflexes): 3 people, 25.00%
Speech Impairment (Adult) (inability to speak (adult)): 3 people, 25.00%
Leukoencephalopathy (disease of the white matter in the brain): 3 people, 25.00%
Weakness: 2 people, 16.67%
Pseudobulbar Palsy (inability to control facial movements (such as chewing and speaking)): 2 people, 16.67%
Herpes Zoster: 2 people, 16.67%
Inflammation: 2 people, 16.67%
Difficulty In Walking: 2 people, 16.67%
Facial Paresis (weakness in facial muscle movement): 2 people, 16.67%
Respiratory Disorder (respiratory disease): 2 people, 16.67%

What are the existing conditions these people have? *

Haematopoietic Neoplasm (clonal disorders of blood cells cause abnormal mass of tissue cell): 2 people, 16.67%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 16.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 8.33%
Acute Leukaemia (blood cancer): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Mercaptopurine and have Peripheral neuropathy?

- Check whether Peripheral neuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Mercaptopurine:

Mercaptopurine (23,013 reports)

Browse all side effects of Mercaptopurine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral neuropathy:

Peripheral neuropathy (504 drugs)

Browse all the conditions that are associated with Peripheral neuropathy:

Peripheral neuropathy (879 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on mercaptopurine (the active ingredients of Mercaptopurine) and Mercaptopurine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.