Metaxalone and Under active thyroid - a phase IV clinical study of FDA data

Summary:

Under active thyroid is reported as a side effect among people who take Metaxalone (metaxalone), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Under active thyroid when taking Metaxalone. It is created by eHealthMe based on reports of 4,277 people who have side effects when taking Metaxalone from the FDA, and is updated regularly.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

What is Under active thyroid?

Under active thyroid is found to be associated with 2,728 drugs and 2,646 conditions by eHealthMe. Check the latest studies of Under active thyroid.

On May, 28, 2026

4,277 people reported to have side effects when taking Metaxalone.
Among them, 13 people (0.3%) have Under active thyroid.

Could Metaxalone cause Under active thyroid?

Among these 13 people:

How long have people been on Metaxalone when they have Under active thyroid? *

What is the gender of people who have Under active thyroid when taking Metaxalone? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Under active thyroid when taking Metaxalone? *

What are other drugs people take besides Metaxalone? *

What are other side effects people have besides Under active thyroid? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Depression: 3 people, 23.08%
Bone Disorder: 2 people, 15.38%
Incisional Hernia (hernia caused by an incompletely-healed surgical wound): 2 people, 15.38%
Fatigue (feeling of tiredness): 2 people, 15.38%
Migraine (headache): 2 people, 15.38%
Neuropathy Peripheral (surface nerve damage): 2 people, 15.38%
Obstructive Sleep Apnea Syndrome (a sleep disorder that involves cessation or significant decrease in airflow in the presence of breathing effort): 2 people, 15.38%
Pain In Extremity: 2 people, 15.38%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 23.08%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 15.38%
Type 2 Diabetes: 1 person, 7.69%
Sinusitis (inflammation of sinus): 1 person, 7.69%
Renal Cell Carcinoma (a kidney cancer): 1 person, 7.69%
Osteoporosis (bones weak and more likely to break): 1 person, 7.69%
Neuralgia (pain in one or more nerves): 1 person, 7.69%
Multiple Allergies (allergy to multiple agents): 1 person, 7.69%
High Blood Cholesterol: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Metaxalone and have Under active thyroid?

- Check whether Under active thyroid is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metaxalone:

Metaxalone (4,452 reports)

Browse all side effects of Metaxalone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Under active thyroid:

Under active thyroid (2,728 drugs)

Browse all the conditions that are associated with Under active thyroid:

Under active thyroid (2,646 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metaxalone (the active ingredients of Metaxalone) and Metaxalone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.