Metformin hydrochloride and Toxic skin eruption - a phase IV clinical study of FDA data

Summary:

Toxic skin eruption is reported as a side effect among people who take Metformin hydrochloride (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Januvia, and have High blood pressure.

The phase IV clinical study analyzes which people have Toxic skin eruption when taking Metformin hydrochloride. It is created by eHealthMe based on reports of 54,785 people who have side effects when taking Metformin hydrochloride from the FDA, and is updated regularly.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,648 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

What is Toxic skin eruption?

Toxic skin eruption (skin breakdown due to toxic substance) is found to be associated with 637 drugs and 1,064 conditions by eHealthMe. Check the latest studies of Toxic skin eruption.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

54,785 people reported to have side effects when taking Metformin hydrochloride.
Among them, 62 people (0.11%) have Toxic skin eruption.

Could Metformin hydrochloride cause Toxic skin eruption?

Among these 62 people:

How long have people been on Metformin hydrochloride when they have Toxic skin eruption? *

What is the gender of people who have Toxic skin eruption when taking Metformin hydrochloride? *

female: 55.93 %
male: 44.07 %

What is the age of people who have Toxic skin eruption when taking Metformin hydrochloride? *

What are other drugs people take besides Metformin hydrochloride? *

What are other side effects people have besides Toxic skin eruption? *

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 9 people, 14.52%
Drug Eruption (adverse drug reaction of the skin): 6 people, 9.68%
Itching: 5 people, 8.06%
Photosensitivity Reaction: 4 people, 6.45%
Erythema Multiforme (a type of hypersensitivity reaction): 4 people, 6.45%
Rashes (redness): 4 people, 6.45%
Leukocytoclastic Vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura): 3 people, 4.84%
Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 3 people, 4.84%
Fever: 3 people, 4.84%
Eosinophilia (eosinophil count in the peripheral blood exceeds): 3 people, 4.84%

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 27.42%
Pain: 9 people, 14.52%
High Blood Cholesterol: 9 people, 14.52%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 12.90%
Sleep Apnea Syndrome: 8 people, 12.90%
Multiple Myeloma (cancer of the plasma cells): 5 people, 8.06%
Dyslipidaemia (abnormal amount of lipids): 4 people, 6.45%
Diarrhea: 4 people, 6.45%
Conjunctivitis (pink eye): 4 people, 6.45%
Incontinence (lack of moderation or self-control): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin hydrochloride and have Toxic skin eruption?

- Check whether Toxic skin eruption is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin hydrochloride:

Metformin hydrochloride (58,648 reports)

Browse all side effects of Metformin hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toxic skin eruption:

Toxic skin eruption (637 drugs)

Browse all the conditions that are associated with Toxic skin eruption:

Toxic skin eruption (1,064 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin hydrochloride) and Metformin hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.